Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.

The delay in regrowth to 10 mm diameter of a transplanted carcinoma in mice was used to estimate the effect of the hypoxic-cell radiosensitizer Ro-07-0582. When 1 mg/g body wt. was given before a single dose of X-rays, a dose-enhancement ratio of 2-0 was found. When the drug was given immediately af...

Descripción completa

Detalles Bibliográficos
Autores principales: Hill, S. A., Fowler, J. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025355/
https://www.ncbi.nlm.nih.gov/pubmed/869984
_version_ 1782136747401936896
author Hill, S. A.
Fowler, J. F.
author_facet Hill, S. A.
Fowler, J. F.
author_sort Hill, S. A.
collection PubMed
description The delay in regrowth to 10 mm diameter of a transplanted carcinoma in mice was used to estimate the effect of the hypoxic-cell radiosensitizer Ro-07-0582. When 1 mg/g body wt. was given before a single dose of X-rays, a dose-enhancement ratio of 2-0 was found. When the drug was given immediately after irradiation, a large cytotoxic effect was observed, equivalent to an enhancement ratio of 1-3. These results were confirmed by determining the X-ray doses required for the local control of 50% of the tumours at 80 days after irradiation. The capacity of the tumour for repair of sublethal X-ray injury within 24 h was similar to that for several normal tissues.
format Text
id pubmed-2025355
institution National Center for Biotechnology Information
language English
publishDate 1977
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20253552009-09-10 Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour. Hill, S. A. Fowler, J. F. Br J Cancer Research Article The delay in regrowth to 10 mm diameter of a transplanted carcinoma in mice was used to estimate the effect of the hypoxic-cell radiosensitizer Ro-07-0582. When 1 mg/g body wt. was given before a single dose of X-rays, a dose-enhancement ratio of 2-0 was found. When the drug was given immediately after irradiation, a large cytotoxic effect was observed, equivalent to an enhancement ratio of 1-3. These results were confirmed by determining the X-ray doses required for the local control of 50% of the tumours at 80 days after irradiation. The capacity of the tumour for repair of sublethal X-ray injury within 24 h was similar to that for several normal tissues. Nature Publishing Group 1977-04 /pmc/articles/PMC2025355/ /pubmed/869984 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hill, S. A.
Fowler, J. F.
Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
title Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
title_full Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
title_fullStr Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
title_full_unstemmed Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
title_short Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
title_sort radiosensitizing and cytocidal effects on hypoxic cells of ro-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025355/
https://www.ncbi.nlm.nih.gov/pubmed/869984
work_keys_str_mv AT hillsa radiosensitizingandcytocidaleffectsonhypoxiccellsofro070582andrepairofxrayinjuryinanexperimentalmousetumour
AT fowlerjf radiosensitizingandcytocidaleffectsonhypoxiccellsofro070582andrepairofxrayinjuryinanexperimentalmousetumour

Ejemplares similares