Aprotinin and growth of Walker 256 carcinosarcoma in the rat.

Growth of the Walker 256 carcinosarcoma implanted within various sites in Spraque-Dawley rats was investigated in animals receiving twice daily i.p. injections of the antiprotease aprotinin. Although administration of aprotinin partially attenuated the growth and lethality of i.p. tumour, no effect...

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Autores principales: Thomson, A. W., Pugh-Humphreys, R. G., Horne, C. H., Tweedle, D. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025359/
https://www.ncbi.nlm.nih.gov/pubmed/300627
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author Thomson, A. W.
Pugh-Humphreys, R. G.
Horne, C. H.
Tweedle, D. J.
author_facet Thomson, A. W.
Pugh-Humphreys, R. G.
Horne, C. H.
Tweedle, D. J.
author_sort Thomson, A. W.
collection PubMed
description Growth of the Walker 256 carcinosarcoma implanted within various sites in Spraque-Dawley rats was investigated in animals receiving twice daily i.p. injections of the antiprotease aprotinin. Although administration of aprotinin partially attenuated the growth and lethality of i.p. tumour, no effect of aprotinin was found on intramuscular tumour development. Furthermore, we were unable to demonstrate unequivocal growth inhibition by aprotinin of lung tumour colonies from i.v. injection of tumour cells. Histological examination of intramuscular and pulmonary tumours revealed little evidence of host cellular immune response in either saline- or aprotinin-treated rats.
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spelling pubmed-20253592009-09-10 Aprotinin and growth of Walker 256 carcinosarcoma in the rat. Thomson, A. W. Pugh-Humphreys, R. G. Horne, C. H. Tweedle, D. J. Br J Cancer Research Article Growth of the Walker 256 carcinosarcoma implanted within various sites in Spraque-Dawley rats was investigated in animals receiving twice daily i.p. injections of the antiprotease aprotinin. Although administration of aprotinin partially attenuated the growth and lethality of i.p. tumour, no effect of aprotinin was found on intramuscular tumour development. Furthermore, we were unable to demonstrate unequivocal growth inhibition by aprotinin of lung tumour colonies from i.v. injection of tumour cells. Histological examination of intramuscular and pulmonary tumours revealed little evidence of host cellular immune response in either saline- or aprotinin-treated rats. Nature Publishing Group 1977-04 /pmc/articles/PMC2025359/ /pubmed/300627 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Thomson, A. W.
Pugh-Humphreys, R. G.
Horne, C. H.
Tweedle, D. J.
Aprotinin and growth of Walker 256 carcinosarcoma in the rat.
title Aprotinin and growth of Walker 256 carcinosarcoma in the rat.
title_full Aprotinin and growth of Walker 256 carcinosarcoma in the rat.
title_fullStr Aprotinin and growth of Walker 256 carcinosarcoma in the rat.
title_full_unstemmed Aprotinin and growth of Walker 256 carcinosarcoma in the rat.
title_short Aprotinin and growth of Walker 256 carcinosarcoma in the rat.
title_sort aprotinin and growth of walker 256 carcinosarcoma in the rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025359/
https://www.ncbi.nlm.nih.gov/pubmed/300627
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