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Immunogenicity of tumour cells modified with various chemicals.
Mouse tumour cells were treated with various chemical modifiers. The number of modifying groups per cell was determined with labelled reagents. The effects of the different modifying groups on the immunogenicity of the tumour cells was tested in syngeneic mice for tumour protection using a challenge...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1977
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025360/ https://www.ncbi.nlm.nih.gov/pubmed/192259 |
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author | Staab, H. J. Anderer, F. A. |
author_facet | Staab, H. J. Anderer, F. A. |
author_sort | Staab, H. J. |
collection | PubMed |
description | Mouse tumour cells were treated with various chemical modifiers. The number of modifying groups per cell was determined with labelled reagents. The effects of the different modifying groups on the immunogenicity of the tumour cells was tested in syngeneic mice for tumour protection using a challenge dose of viable cells at 1000 or 10,000 time LD100. Best protection was obtained after immunization of animals with tumour cells modified with dimethylsulphate or acetic anhydride, or with glutardialdehyde-fixed cells treated with a carbodiimide and methylamine. Up to 40% of the animals remained tumour-free. The other animals exhibited a greatly increased mean survival time. The post-challenge sera showed no detectable amounts of antibodies against the tumour cells. |
format | Text |
id | pubmed-2025360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1977 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20253602009-09-10 Immunogenicity of tumour cells modified with various chemicals. Staab, H. J. Anderer, F. A. Br J Cancer Research Article Mouse tumour cells were treated with various chemical modifiers. The number of modifying groups per cell was determined with labelled reagents. The effects of the different modifying groups on the immunogenicity of the tumour cells was tested in syngeneic mice for tumour protection using a challenge dose of viable cells at 1000 or 10,000 time LD100. Best protection was obtained after immunization of animals with tumour cells modified with dimethylsulphate or acetic anhydride, or with glutardialdehyde-fixed cells treated with a carbodiimide and methylamine. Up to 40% of the animals remained tumour-free. The other animals exhibited a greatly increased mean survival time. The post-challenge sera showed no detectable amounts of antibodies against the tumour cells. Nature Publishing Group 1977-04 /pmc/articles/PMC2025360/ /pubmed/192259 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Staab, H. J. Anderer, F. A. Immunogenicity of tumour cells modified with various chemicals. |
title | Immunogenicity of tumour cells modified with various chemicals. |
title_full | Immunogenicity of tumour cells modified with various chemicals. |
title_fullStr | Immunogenicity of tumour cells modified with various chemicals. |
title_full_unstemmed | Immunogenicity of tumour cells modified with various chemicals. |
title_short | Immunogenicity of tumour cells modified with various chemicals. |
title_sort | immunogenicity of tumour cells modified with various chemicals. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025360/ https://www.ncbi.nlm.nih.gov/pubmed/192259 |
work_keys_str_mv | AT staabhj immunogenicityoftumourcellsmodifiedwithvariouschemicals AT andererfa immunogenicityoftumourcellsmodifiedwithvariouschemicals |