Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice.

Two proprietary semi-permanent hair dyes were tested for carcinogenicity in A and DBAf mice by repeated topical applications in aqueous acetone. Mice of both strains developed lymphoid tumours but experimental differences were marked only in DBAf mice. A number of tumours of the ovary and uterus, an...

Descripción completa

Detalles Bibliográficos
Autores principales: Searle, C. E., Jones, E. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025369/
https://www.ncbi.nlm.nih.gov/pubmed/588414
_version_ 1782136750183809024
author Searle, C. E.
Jones, E. L.
author_facet Searle, C. E.
Jones, E. L.
author_sort Searle, C. E.
collection PubMed
description Two proprietary semi-permanent hair dyes were tested for carcinogenicity in A and DBAf mice by repeated topical applications in aqueous acetone. Mice of both strains developed lymphoid tumours but experimental differences were marked only in DBAf mice. A number of tumours of the ovary and uterus, and some skin papillomas near the penis, occured in dye-treated but not in control DBAf mice. As many hair-dye constituents are known mutagens, adequate carcinogenicity testing of these substances, and epidemiological study of exposed human populations, are needed for evaluating possible health hazard from hair dyeing. IMAGES:
format Text
id pubmed-2025369
institution National Center for Biotechnology Information
language English
publishDate 1977
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20253692009-09-10 Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice. Searle, C. E. Jones, E. L. Br J Cancer Research Article Two proprietary semi-permanent hair dyes were tested for carcinogenicity in A and DBAf mice by repeated topical applications in aqueous acetone. Mice of both strains developed lymphoid tumours but experimental differences were marked only in DBAf mice. A number of tumours of the ovary and uterus, and some skin papillomas near the penis, occured in dye-treated but not in control DBAf mice. As many hair-dye constituents are known mutagens, adequate carcinogenicity testing of these substances, and epidemiological study of exposed human populations, are needed for evaluating possible health hazard from hair dyeing. IMAGES: Nature Publishing Group 1977-10 /pmc/articles/PMC2025369/ /pubmed/588414 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Searle, C. E.
Jones, E. L.
Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice.
title Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice.
title_full Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice.
title_fullStr Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice.
title_full_unstemmed Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice.
title_short Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice.
title_sort effects of repeated applications of two semi-permanent hair dyes to the skin of a and dbaf mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025369/
https://www.ncbi.nlm.nih.gov/pubmed/588414
work_keys_str_mv AT searlece effectsofrepeatedapplicationsoftwosemipermanenthairdyestotheskinofaanddbafmice
AT jonesel effectsofrepeatedapplicationsoftwosemipermanenthairdyestotheskinofaanddbafmice

Ejemplares similares