The effect of cyclophosphamide on MSV-H oncogenesis.

The effect of cyclophosphamide on MSV-H oncogensis and the immune response of young mice has been investigated. A single, sublethal dose (100 and 50 mg/kg of cyclophosphamide) in 8-day-old mice given 24 h before or after MSV-H infection led to an earlier and lower incidence of tumours in comparison...

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Detalles Bibliográficos
Autores principales: Branca, M., Nicoletti, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025375/
https://www.ncbi.nlm.nih.gov/pubmed/201258
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author Branca, M.
Nicoletti, L.
author_facet Branca, M.
Nicoletti, L.
author_sort Branca, M.
collection PubMed
description The effect of cyclophosphamide on MSV-H oncogensis and the immune response of young mice has been investigated. A single, sublethal dose (100 and 50 mg/kg of cyclophosphamide) in 8-day-old mice given 24 h before or after MSV-H infection led to an earlier and lower incidence of tumours in comparison with controls infected only with MSV-H. The protective effect of cyclophosphamide, and the mechanism of action of both cyclophosphamide and MSV-H on the target cells, mesenchymal cells in rapid replication, as well the immunological implications of the findings are discussed. IMAGES:
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spelling pubmed-20253752009-09-10 The effect of cyclophosphamide on MSV-H oncogenesis. Branca, M. Nicoletti, L. Br J Cancer Research Article The effect of cyclophosphamide on MSV-H oncogensis and the immune response of young mice has been investigated. A single, sublethal dose (100 and 50 mg/kg of cyclophosphamide) in 8-day-old mice given 24 h before or after MSV-H infection led to an earlier and lower incidence of tumours in comparison with controls infected only with MSV-H. The protective effect of cyclophosphamide, and the mechanism of action of both cyclophosphamide and MSV-H on the target cells, mesenchymal cells in rapid replication, as well the immunological implications of the findings are discussed. IMAGES: Nature Publishing Group 1977-10 /pmc/articles/PMC2025375/ /pubmed/201258 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Branca, M.
Nicoletti, L.
The effect of cyclophosphamide on MSV-H oncogenesis.
title The effect of cyclophosphamide on MSV-H oncogenesis.
title_full The effect of cyclophosphamide on MSV-H oncogenesis.
title_fullStr The effect of cyclophosphamide on MSV-H oncogenesis.
title_full_unstemmed The effect of cyclophosphamide on MSV-H oncogenesis.
title_short The effect of cyclophosphamide on MSV-H oncogenesis.
title_sort effect of cyclophosphamide on msv-h oncogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025375/
https://www.ncbi.nlm.nih.gov/pubmed/201258
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