Effect of di-isopropanolnitrosamine in European hamsters.

The carcinogenic effects of di-isopropanolnitrosamine (DIPN) were tested in hibernating and non-hibernating European hamsters. The results obtained were compared with those produced by the same substance in Syrian golden hamsters and Sprague-Dawley rats. In European hamsters, tumours were produced i...

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Autores principales: Reznik, G., Mohr, U.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025380/
https://www.ncbi.nlm.nih.gov/pubmed/588415
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author Reznik, G.
Mohr, U.
author_facet Reznik, G.
Mohr, U.
author_sort Reznik, G.
collection PubMed
description The carcinogenic effects of di-isopropanolnitrosamine (DIPN) were tested in hibernating and non-hibernating European hamsters. The results obtained were compared with those produced by the same substance in Syrian golden hamsters and Sprague-Dawley rats. In European hamsters, tumours were produced in the nasal cavity, trachea, lung, liver and pancreas. The main target organs were the anterior part of the nasal cavity and liver. Only cholangiomas and cholangiocarcinomas were found in the liver. Early changes in the intrahepatic bile ducts and duct epithelium of the pancreas were seen 4 weeks after treatment was started. Fourteen out of 144 treated hamsters developed pancreatic-duct tumours, 2 of which were malignant. The tumorigenic response in the target organs was lower in hibernating than in non-hibernating animals. IMAGES:
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spelling pubmed-20253802009-09-10 Effect of di-isopropanolnitrosamine in European hamsters. Reznik, G. Mohr, U. Br J Cancer Research Article The carcinogenic effects of di-isopropanolnitrosamine (DIPN) were tested in hibernating and non-hibernating European hamsters. The results obtained were compared with those produced by the same substance in Syrian golden hamsters and Sprague-Dawley rats. In European hamsters, tumours were produced in the nasal cavity, trachea, lung, liver and pancreas. The main target organs were the anterior part of the nasal cavity and liver. Only cholangiomas and cholangiocarcinomas were found in the liver. Early changes in the intrahepatic bile ducts and duct epithelium of the pancreas were seen 4 weeks after treatment was started. Fourteen out of 144 treated hamsters developed pancreatic-duct tumours, 2 of which were malignant. The tumorigenic response in the target organs was lower in hibernating than in non-hibernating animals. IMAGES: Nature Publishing Group 1977-10 /pmc/articles/PMC2025380/ /pubmed/588415 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Reznik, G.
Mohr, U.
Effect of di-isopropanolnitrosamine in European hamsters.
title Effect of di-isopropanolnitrosamine in European hamsters.
title_full Effect of di-isopropanolnitrosamine in European hamsters.
title_fullStr Effect of di-isopropanolnitrosamine in European hamsters.
title_full_unstemmed Effect of di-isopropanolnitrosamine in European hamsters.
title_short Effect of di-isopropanolnitrosamine in European hamsters.
title_sort effect of di-isopropanolnitrosamine in european hamsters.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025380/
https://www.ncbi.nlm.nih.gov/pubmed/588415
work_keys_str_mv AT reznikg effectofdiisopropanolnitrosamineineuropeanhamsters
AT mohru effectofdiisopropanolnitrosamineineuropeanhamsters

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