Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity.

The effector arm of antibody-dependent cellular cytotoxicity (ADCC) was evaluated using 51Cr-labelled chicken erythrocytes as targets in BALB/c mice transplanted with the Moloney sarcoma virus-induced tumours T-MSV and MS2, and in C57BL/6 mice transplanted with the chemically induced FS6 sarcoma, Le...

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Autores principales: Mantovani, A., Polentarutti, N., Alessandri, G., Vecchi, A., Giuliani, F., Spreafico, F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025381/
https://www.ncbi.nlm.nih.gov/pubmed/588412
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author Mantovani, A.
Polentarutti, N.
Alessandri, G.
Vecchi, A.
Giuliani, F.
Spreafico, F.
author_facet Mantovani, A.
Polentarutti, N.
Alessandri, G.
Vecchi, A.
Giuliani, F.
Spreafico, F.
author_sort Mantovani, A.
collection PubMed
description The effector arm of antibody-dependent cellular cytotoxicity (ADCC) was evaluated using 51Cr-labelled chicken erythrocytes as targets in BALB/c mice transplanted with the Moloney sarcoma virus-induced tumours T-MSV and MS2, and in C57BL/6 mice transplanted with the chemically induced FS6 sarcoma, Lewis lung carcinoma and B16 melanoma. Tumour-bearing animals showed higher levels of ADCC than normal mice, a stimulation confirmed in MS2-bearing mice, using SL2 lymphoma cells as targets in a cytostasis assay. ADCC effector-cell capacity was higher in animals transplanted with the immunogenic, spontaneously regressing T-MSV than in mice bearing the poorly immunogenic metastasizing MS2 sarcoma. The increased ADCC activity detectable in the spleen of tumour-bearing hosts was not abolished by removal of phagocytic-adherent cells.
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spelling pubmed-20253812009-09-10 Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity. Mantovani, A. Polentarutti, N. Alessandri, G. Vecchi, A. Giuliani, F. Spreafico, F. Br J Cancer Research Article The effector arm of antibody-dependent cellular cytotoxicity (ADCC) was evaluated using 51Cr-labelled chicken erythrocytes as targets in BALB/c mice transplanted with the Moloney sarcoma virus-induced tumours T-MSV and MS2, and in C57BL/6 mice transplanted with the chemically induced FS6 sarcoma, Lewis lung carcinoma and B16 melanoma. Tumour-bearing animals showed higher levels of ADCC than normal mice, a stimulation confirmed in MS2-bearing mice, using SL2 lymphoma cells as targets in a cytostasis assay. ADCC effector-cell capacity was higher in animals transplanted with the immunogenic, spontaneously regressing T-MSV than in mice bearing the poorly immunogenic metastasizing MS2 sarcoma. The increased ADCC activity detectable in the spleen of tumour-bearing hosts was not abolished by removal of phagocytic-adherent cells. Nature Publishing Group 1977-10 /pmc/articles/PMC2025381/ /pubmed/588412 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Mantovani, A.
Polentarutti, N.
Alessandri, G.
Vecchi, A.
Giuliani, F.
Spreafico, F.
Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity.
title Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity.
title_full Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity.
title_fullStr Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity.
title_full_unstemmed Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity.
title_short Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity.
title_sort activation of k cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025381/
https://www.ncbi.nlm.nih.gov/pubmed/588412
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