Localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques.

Cellular localization of carcinoembryonic antigen (CEA) in medullary thyroid carcinoma was studied in ethanol-fixed, paraffin-embedded specimens using the direct and indirect immunofluorescent techniques. It was demonstrated that CEA was present not only on the surface, but also in the cytoplasm of...

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Autor principal: Hamada, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025392/
https://www.ncbi.nlm.nih.gov/pubmed/337999
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author Hamada, S.
Hamada, S.
author_facet Hamada, S.
Hamada, S.
author_sort Hamada, S.
collection PubMed
description Cellular localization of carcinoembryonic antigen (CEA) in medullary thyroid carcinoma was studied in ethanol-fixed, paraffin-embedded specimens using the direct and indirect immunofluorescent techniques. It was demonstrated that CEA was present not only on the surface, but also in the cytoplasm of tumour cells. The immunofluorescence in the cytoplasm differed considerably in intensity from cell to cell. By contrast, no significant fluorescence was demonstrated in tissues of other types of thyroid adenocarcinoma, adenoma. Graves' disease and normal thyroid, with few exceptions. The results obtained indicate that CEA is actively produced by the tumour cells, and is present as a constituent of the cell membrane. IMAGES:
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spelling pubmed-20253922009-09-10 Localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques. Hamada, S. Hamada, S. Br J Cancer Research Article Cellular localization of carcinoembryonic antigen (CEA) in medullary thyroid carcinoma was studied in ethanol-fixed, paraffin-embedded specimens using the direct and indirect immunofluorescent techniques. It was demonstrated that CEA was present not only on the surface, but also in the cytoplasm of tumour cells. The immunofluorescence in the cytoplasm differed considerably in intensity from cell to cell. By contrast, no significant fluorescence was demonstrated in tissues of other types of thyroid adenocarcinoma, adenoma. Graves' disease and normal thyroid, with few exceptions. The results obtained indicate that CEA is actively produced by the tumour cells, and is present as a constituent of the cell membrane. IMAGES: Nature Publishing Group 1977-11 /pmc/articles/PMC2025392/ /pubmed/337999 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hamada, S.
Hamada, S.
Localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques.
title Localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques.
title_full Localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques.
title_fullStr Localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques.
title_full_unstemmed Localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques.
title_short Localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques.
title_sort localization of carcinoembryonic antigen in medullary thyroid carcinoma by immunofluorescent techniques.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025392/
https://www.ncbi.nlm.nih.gov/pubmed/337999
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