Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease.

A comparative study has been made of fibroblasts obtained from patients with differing susceptibilities to malignant disease, both with respect to their chromosome complements and their transformation with SV40 virus. Fibroblasts from 2 Bloom's syndrome patients were found not to have raised SV...

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Detalles Bibliográficos
Autores principales: Webb, T., Harding, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025401/
https://www.ncbi.nlm.nih.gov/pubmed/201260
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author Webb, T.
Harding, M.
author_facet Webb, T.
Harding, M.
author_sort Webb, T.
collection PubMed
description A comparative study has been made of fibroblasts obtained from patients with differing susceptibilities to malignant disease, both with respect to their chromosome complements and their transformation with SV40 virus. Fibroblasts from 2 Bloom's syndrome patients were found not to have raised SV40 transformation rates and no correlation was found between chromosome abnormality per se and transformation. Of 2 cell types with greatly increased rates, one was derived from a neurofibromatosis patient and the other from an A-T heterozygote. When SV40 DNA was employed as the transforming agent for the latter, the transformation rate was no longer raised. IMAGES:
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spelling pubmed-20254012009-09-10 Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease. Webb, T. Harding, M. Br J Cancer Research Article A comparative study has been made of fibroblasts obtained from patients with differing susceptibilities to malignant disease, both with respect to their chromosome complements and their transformation with SV40 virus. Fibroblasts from 2 Bloom's syndrome patients were found not to have raised SV40 transformation rates and no correlation was found between chromosome abnormality per se and transformation. Of 2 cell types with greatly increased rates, one was derived from a neurofibromatosis patient and the other from an A-T heterozygote. When SV40 DNA was employed as the transforming agent for the latter, the transformation rate was no longer raised. IMAGES: Nature Publishing Group 1977-11 /pmc/articles/PMC2025401/ /pubmed/201260 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Webb, T.
Harding, M.
Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease.
title Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease.
title_full Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease.
title_fullStr Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease.
title_full_unstemmed Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease.
title_short Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease.
title_sort chromosome complement and sv40 transformation of cells from patients susceptible to malignant disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025401/
https://www.ncbi.nlm.nih.gov/pubmed/201260
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