Assessment of inherent fluctuations of mitotic and labelling indices of human tumours.

A method is presented to evaluate the influence of statistical errors and inherent variation on the determination of mitotic and labelling indices of human tumours. In most of the experiments reported here, sufficient cells were counted to yield a statistical error which is small in comparison to th...

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Autores principales: Aherne, W. A., Camplejohn, R. S., Al-Wiswasy, M., Ford, D., Kellerer, A. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025402/
https://www.ncbi.nlm.nih.gov/pubmed/201259
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author Aherne, W. A.
Camplejohn, R. S.
Al-Wiswasy, M.
Ford, D.
Kellerer, A. M.
author_facet Aherne, W. A.
Camplejohn, R. S.
Al-Wiswasy, M.
Ford, D.
Kellerer, A. M.
author_sort Aherne, W. A.
collection PubMed
description A method is presented to evaluate the influence of statistical errors and inherent variation on the determination of mitotic and labelling indices of human tumours. In most of the experiments reported here, sufficient cells were counted to yield a statistical error which is small in comparison to the inherent differences in the proliferative indices, both between different sites in the same tumour and between different tumours of the same histological type. These inherent fluctuations are, theefore, a critical factor in cell kinetic studies of human tumours.
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spelling pubmed-20254022009-09-10 Assessment of inherent fluctuations of mitotic and labelling indices of human tumours. Aherne, W. A. Camplejohn, R. S. Al-Wiswasy, M. Ford, D. Kellerer, A. M. Br J Cancer Research Article A method is presented to evaluate the influence of statistical errors and inherent variation on the determination of mitotic and labelling indices of human tumours. In most of the experiments reported here, sufficient cells were counted to yield a statistical error which is small in comparison to the inherent differences in the proliferative indices, both between different sites in the same tumour and between different tumours of the same histological type. These inherent fluctuations are, theefore, a critical factor in cell kinetic studies of human tumours. Nature Publishing Group 1977-11 /pmc/articles/PMC2025402/ /pubmed/201259 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Aherne, W. A.
Camplejohn, R. S.
Al-Wiswasy, M.
Ford, D.
Kellerer, A. M.
Assessment of inherent fluctuations of mitotic and labelling indices of human tumours.
title Assessment of inherent fluctuations of mitotic and labelling indices of human tumours.
title_full Assessment of inherent fluctuations of mitotic and labelling indices of human tumours.
title_fullStr Assessment of inherent fluctuations of mitotic and labelling indices of human tumours.
title_full_unstemmed Assessment of inherent fluctuations of mitotic and labelling indices of human tumours.
title_short Assessment of inherent fluctuations of mitotic and labelling indices of human tumours.
title_sort assessment of inherent fluctuations of mitotic and labelling indices of human tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025402/
https://www.ncbi.nlm.nih.gov/pubmed/201259
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