Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors.

A micro-assay designed to assess the capacity of peripheral blood mononuclear cells to differentiate in vitro into mature macrophages is described. In patients with "final common pathway" malignant melanoma, there was a highly significant deficiency in macrophage precursors (MPs). By conve...

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Detalles Bibliográficos
Autores principales: Currie, G. A., Hedley, D. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025452/
https://www.ncbi.nlm.nih.gov/pubmed/889676
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author Currie, G. A.
Hedley, D. W.
author_facet Currie, G. A.
Hedley, D. W.
author_sort Currie, G. A.
collection PubMed
description A micro-assay designed to assess the capacity of peripheral blood mononuclear cells to differentiate in vitro into mature macrophages is described. In patients with "final common pathway" malignant melanoma, there was a highly significant deficiency in macrophage precursors (MPs). By conventional morphological criteria such patients did not show a significant monocytopenia. Serum factors do not seem to contribute to the MP defect in the patients. We conclude that these patients have an intrinsic functional defect in their peripheral blood monocytes, but the mechanisms responsible for this defect are as yet unknown.
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spelling pubmed-20254522009-09-10 Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors. Currie, G. A. Hedley, D. W. Br J Cancer Research Article A micro-assay designed to assess the capacity of peripheral blood mononuclear cells to differentiate in vitro into mature macrophages is described. In patients with "final common pathway" malignant melanoma, there was a highly significant deficiency in macrophage precursors (MPs). By conventional morphological criteria such patients did not show a significant monocytopenia. Serum factors do not seem to contribute to the MP defect in the patients. We conclude that these patients have an intrinsic functional defect in their peripheral blood monocytes, but the mechanisms responsible for this defect are as yet unknown. Nature Publishing Group 1977-07 /pmc/articles/PMC2025452/ /pubmed/889676 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Currie, G. A.
Hedley, D. W.
Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors.
title Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors.
title_full Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors.
title_fullStr Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors.
title_full_unstemmed Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors.
title_short Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors.
title_sort monocytes and macrophages in malignant melanoma. i. peripheral blood macrophage precursors.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025452/
https://www.ncbi.nlm.nih.gov/pubmed/889676
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AT hedleydw monocytesandmacrophagesinmalignantmelanomaiperipheralbloodmacrophageprecursors

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