Null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.

Cultured cells established from the bone marrow of a child with null-cell acute lymphoblastic leukaemia (ALL) have been studied. After 8 months in vitro, the cytological, cytochemical and immunological properties of the cultured cells were very similar to those of the patient's cells. Many of t...

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Autores principales: Karpas, A., Sandler, R. M., Thorburn, R. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025467/
https://www.ncbi.nlm.nih.gov/pubmed/199225
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author Karpas, A.
Sandler, R. M.
Thorburn, R. J.
author_facet Karpas, A.
Sandler, R. M.
Thorburn, R. J.
author_sort Karpas, A.
collection PubMed
description Cultured cells established from the bone marrow of a child with null-cell acute lymphoblastic leukaemia (ALL) have been studied. After 8 months in vitro, the cytological, cytochemical and immunological properties of the cultured cells were very similar to those of the patient's cells. Many of the cultured cells had morphological and cytogenetic abnormalities often found in acute leukaemia. The cells were EBNA-negative. This unique culture of ALL-derived null cells might provide information as to the aetiology and origin of malignant cells. IMAGES:
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spelling pubmed-20254672009-09-10 Null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia. Karpas, A. Sandler, R. M. Thorburn, R. J. Br J Cancer Research Article Cultured cells established from the bone marrow of a child with null-cell acute lymphoblastic leukaemia (ALL) have been studied. After 8 months in vitro, the cytological, cytochemical and immunological properties of the cultured cells were very similar to those of the patient's cells. Many of the cultured cells had morphological and cytogenetic abnormalities often found in acute leukaemia. The cells were EBNA-negative. This unique culture of ALL-derived null cells might provide information as to the aetiology and origin of malignant cells. IMAGES: Nature Publishing Group 1977-08 /pmc/articles/PMC2025467/ /pubmed/199225 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Karpas, A.
Sandler, R. M.
Thorburn, R. J.
Null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.
title Null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.
title_full Null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.
title_fullStr Null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.
title_full_unstemmed Null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.
title_short Null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.
title_sort null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025467/
https://www.ncbi.nlm.nih.gov/pubmed/199225
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