Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.

Mitochondrial fractions isolated from tumours induced with the respiratory inhibitor rotenone lack respiratory control, oxidative phosphorylation, are partially or totally insensitive to cyanide and have a near-normal content of respiratory carriers. These characteristics are more similar to those o...

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Autores principales: Gosálvez, M., Díaz-Gil, J., Coloma, J., Salganicoff, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025468/
https://www.ncbi.nlm.nih.gov/pubmed/911663
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author Gosálvez, M.
Díaz-Gil, J.
Coloma, J.
Salganicoff, L.
author_facet Gosálvez, M.
Díaz-Gil, J.
Coloma, J.
Salganicoff, L.
author_sort Gosálvez, M.
collection PubMed
description Mitochondrial fractions isolated from tumours induced with the respiratory inhibitor rotenone lack respiratory control, oxidative phosphorylation, are partially or totally insensitive to cyanide and have a near-normal content of respiratory carriers. These characteristics are more similar to those of mitochondria from atrophic mammary gland than to those of mitochondria from spontaneous mammary adenomas. Thus, the characteristic structural and biochemical mitochondrial alteration of rotenone-induced tumours would represent a lack of mitochondrial differentiation as the tumour develops from the atrophic mammary gland. Slices of rotenone-induced tumours are insensitive to oligomycin and dinitrophenol, thus indicating that glycolysis would be their sole source of metabolic energy. IMAGES:
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spelling pubmed-20254682009-09-10 Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours. Gosálvez, M. Díaz-Gil, J. Coloma, J. Salganicoff, L. Br J Cancer Research Article Mitochondrial fractions isolated from tumours induced with the respiratory inhibitor rotenone lack respiratory control, oxidative phosphorylation, are partially or totally insensitive to cyanide and have a near-normal content of respiratory carriers. These characteristics are more similar to those of mitochondria from atrophic mammary gland than to those of mitochondria from spontaneous mammary adenomas. Thus, the characteristic structural and biochemical mitochondrial alteration of rotenone-induced tumours would represent a lack of mitochondrial differentiation as the tumour develops from the atrophic mammary gland. Slices of rotenone-induced tumours are insensitive to oligomycin and dinitrophenol, thus indicating that glycolysis would be their sole source of metabolic energy. IMAGES: Nature Publishing Group 1977-08 /pmc/articles/PMC2025468/ /pubmed/911663 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gosálvez, M.
Díaz-Gil, J.
Coloma, J.
Salganicoff, L.
Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.
title Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.
title_full Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.
title_fullStr Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.
title_full_unstemmed Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.
title_short Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.
title_sort spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025468/
https://www.ncbi.nlm.nih.gov/pubmed/911663
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AT salganicoffl spectralandmetaboliccharacteristicsofmitochondrialfractionsfromrotenoneinducedtumours

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