Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.

Concentrations of methylprednisolone which have lethal effects on human lymphoblastoid cell lines in vitro cause a reduction both in the uptake of uridine and thymidine into acid-soluble material and their incorporation into acid-insoluble material. These effects are virtually instantaneous, which i...

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Detalles Bibliográficos
Autores principales: Waddell, A. W., Bird, C. C., Currie, A. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025470/
https://www.ncbi.nlm.nih.gov/pubmed/269741
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author Waddell, A. W.
Bird, C. C.
Currie, A. R.
author_facet Waddell, A. W.
Bird, C. C.
Currie, A. R.
author_sort Waddell, A. W.
collection PubMed
description Concentrations of methylprednisolone which have lethal effects on human lymphoblastoid cell lines in vitro cause a reduction both in the uptake of uridine and thymidine into acid-soluble material and their incorporation into acid-insoluble material. These effects are virtually instantaneous, which indicates that they do not depend on alterations in gene activity. Normal uptake of nucleosides into cells is by both simple and facilitated diffusion, and methylprednisolone appears to act directly on the cell surface to inhibit only facilitated diffusion uptake.
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spelling pubmed-20254702009-09-10 Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line. Waddell, A. W. Bird, C. C. Currie, A. R. Br J Cancer Research Article Concentrations of methylprednisolone which have lethal effects on human lymphoblastoid cell lines in vitro cause a reduction both in the uptake of uridine and thymidine into acid-soluble material and their incorporation into acid-insoluble material. These effects are virtually instantaneous, which indicates that they do not depend on alterations in gene activity. Normal uptake of nucleosides into cells is by both simple and facilitated diffusion, and methylprednisolone appears to act directly on the cell surface to inhibit only facilitated diffusion uptake. Nature Publishing Group 1977-08 /pmc/articles/PMC2025470/ /pubmed/269741 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Waddell, A. W.
Bird, C. C.
Currie, A. R.
Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.
title Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.
title_full Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.
title_fullStr Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.
title_full_unstemmed Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.
title_short Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.
title_sort effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025470/
https://www.ncbi.nlm.nih.gov/pubmed/269741
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