Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.

The relationship between the utilization of 3H-thymidine in situ ([3H]-TdR fractional incorporation or TFI) and tumour growth delay after treatment with various cytotoxic agents has been examined. It is shown that (a) it is not possible to predict tumour growth delay, or to select the most effective...

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Autores principales: Houghton, P. J., Houghton, J. A., Taylor, D. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025473/
https://www.ncbi.nlm.nih.gov/pubmed/911658
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author Houghton, P. J.
Houghton, J. A.
Taylor, D. M.
author_facet Houghton, P. J.
Houghton, J. A.
Taylor, D. M.
author_sort Houghton, P. J.
collection PubMed
description The relationship between the utilization of 3H-thymidine in situ ([3H]-TdR fractional incorporation or TFI) and tumour growth delay after treatment with various cytotoxic agents has been examined. It is shown that (a) it is not possible to predict tumour growth delay, or to select the most effective agent, from changes in TFI 1 day after treatment; (b) there is a good correlation between tumour growth delay and the time for recovery of TFI to the pretreatment level; (c) there is a relationship within a tumour line between the depression of TFI 4 days after treatment and growth dealy induced by the same treatment. This relationship appears to be independent of the mechanism by which the agent exerts its cytotoxic effect.
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spelling pubmed-20254732009-09-10 Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts. Houghton, P. J. Houghton, J. A. Taylor, D. M. Br J Cancer Research Article The relationship between the utilization of 3H-thymidine in situ ([3H]-TdR fractional incorporation or TFI) and tumour growth delay after treatment with various cytotoxic agents has been examined. It is shown that (a) it is not possible to predict tumour growth delay, or to select the most effective agent, from changes in TFI 1 day after treatment; (b) there is a good correlation between tumour growth delay and the time for recovery of TFI to the pretreatment level; (c) there is a relationship within a tumour line between the depression of TFI 4 days after treatment and growth dealy induced by the same treatment. This relationship appears to be independent of the mechanism by which the agent exerts its cytotoxic effect. Nature Publishing Group 1977-08 /pmc/articles/PMC2025473/ /pubmed/911658 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Houghton, P. J.
Houghton, J. A.
Taylor, D. M.
Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
title Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
title_full Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
title_fullStr Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
title_full_unstemmed Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
title_short Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
title_sort effects of cytotoxic agents on tdr incorporation and growth delay in human colonic tumour xenografts.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025473/
https://www.ncbi.nlm.nih.gov/pubmed/911658
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