Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.

The ovaries of children with abdominal tumours were studied in 12 autopsy specimens. Ovaries from 25 children who died in accidents or after a short acute disease served as controls. All ovaries from normal children showed follicle growth, but follicle development was inhibited in 67% of the childre...

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Autores principales: Himelstein-Braw, R., Peters, H., Faber, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025478/
https://www.ncbi.nlm.nih.gov/pubmed/911665
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author Himelstein-Braw, R.
Peters, H.
Faber, M.
author_facet Himelstein-Braw, R.
Peters, H.
Faber, M.
author_sort Himelstein-Braw, R.
collection PubMed
description The ovaries of children with abdominal tumours were studied in 12 autopsy specimens. Ovaries from 25 children who died in accidents or after a short acute disease served as controls. All ovaries from normal children showed follicle growth, but follicle development was inhibited in 67% of the children with abdominal tumours. The effect of treatment with cytotoxic drugs and/or abdominal irradiation on ovarian morphology was investigated. Normal ovaries were found only in children who had received no chemotherapy or a short course. All patients who had been treated with radiation therapy either alone or in conjunction with chemotherapy had severely damaged ovaries: follicle growth was inhibited in all cases, and the number of small non-growing follicles was markedly reduced in most. It is argued that abdominal irradiation might impair follicle development as well as destroy small follicles. IMAGES:
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spelling pubmed-20254782009-09-10 Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours. Himelstein-Braw, R. Peters, H. Faber, M. Br J Cancer Research Article The ovaries of children with abdominal tumours were studied in 12 autopsy specimens. Ovaries from 25 children who died in accidents or after a short acute disease served as controls. All ovaries from normal children showed follicle growth, but follicle development was inhibited in 67% of the children with abdominal tumours. The effect of treatment with cytotoxic drugs and/or abdominal irradiation on ovarian morphology was investigated. Normal ovaries were found only in children who had received no chemotherapy or a short course. All patients who had been treated with radiation therapy either alone or in conjunction with chemotherapy had severely damaged ovaries: follicle growth was inhibited in all cases, and the number of small non-growing follicles was markedly reduced in most. It is argued that abdominal irradiation might impair follicle development as well as destroy small follicles. IMAGES: Nature Publishing Group 1977-08 /pmc/articles/PMC2025478/ /pubmed/911665 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Himelstein-Braw, R.
Peters, H.
Faber, M.
Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
title Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
title_full Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
title_fullStr Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
title_full_unstemmed Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
title_short Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
title_sort influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025478/
https://www.ncbi.nlm.nih.gov/pubmed/911665
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AT faberm influenceofirradiationandchemotherapyontheovariesofchildrenwithabdominaltumours

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