Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.

Mitomycin-treated transplantable Moloney virus-induced lymphatic leukaemia cells (YC8) not only failed to stimulate normal allogeneic lymphocytes in one-way mixed leucocyte culture (MLC) but also exerted a strong inhibitory effect on the proliferative response of normal lymphocytes, in MLC and after...

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Autores principales: Biasi, G., Collavo, D., Colombatti, A., Chieco-Bianchi, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025493/
https://www.ncbi.nlm.nih.gov/pubmed/140697
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author Biasi, G.
Collavo, D.
Colombatti, A.
Chieco-Bianchi, L.
author_facet Biasi, G.
Collavo, D.
Colombatti, A.
Chieco-Bianchi, L.
author_sort Biasi, G.
collection PubMed
description Mitomycin-treated transplantable Moloney virus-induced lymphatic leukaemia cells (YC8) not only failed to stimulate normal allogeneic lymphocytes in one-way mixed leucocyte culture (MLC) but also exerted a strong inhibitory effect on the proliferative response of normal lymphocytes, in MLC and after stimulation by mitogens. Potentially inhibitory factors which could be released in the culture fluids by the YC8 cells were not found, but a YC8-derived adherent cell subpopulation was identified as being responsible for the in vitro suppression.
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spelling pubmed-20254932009-09-10 Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity. Biasi, G. Collavo, D. Colombatti, A. Chieco-Bianchi, L. Br J Cancer Research Article Mitomycin-treated transplantable Moloney virus-induced lymphatic leukaemia cells (YC8) not only failed to stimulate normal allogeneic lymphocytes in one-way mixed leucocyte culture (MLC) but also exerted a strong inhibitory effect on the proliferative response of normal lymphocytes, in MLC and after stimulation by mitogens. Potentially inhibitory factors which could be released in the culture fluids by the YC8 cells were not found, but a YC8-derived adherent cell subpopulation was identified as being responsible for the in vitro suppression. Nature Publishing Group 1977-05 /pmc/articles/PMC2025493/ /pubmed/140697 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Biasi, G.
Collavo, D.
Colombatti, A.
Chieco-Bianchi, L.
Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.
title Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.
title_full Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.
title_fullStr Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.
title_full_unstemmed Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.
title_short Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.
title_sort inhibitory effect of yc8 leukaemia cell line on in vitro lymphocyte reactivity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025493/
https://www.ncbi.nlm.nih.gov/pubmed/140697
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AT colombattia inhibitoryeffectofyc8leukaemiacelllineoninvitrolymphocytereactivity
AT chiecobianchil inhibitoryeffectofyc8leukaemiacelllineoninvitrolymphocytereactivity

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