Effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours.

Administration of ovine prolactin alone supported growth of hormone-dependent GR mouse mammary tumours. Growth of hormone-independent tumours was not stimulated. Furthermore, administration of bromocriptine, a compound that inhibits release of prolactin from the pituitary gland, was shown to inhibit...

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Autores principales: Briand, P., Thorpe, S. M., Daehnfeldt, J. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025523/
https://www.ncbi.nlm.nih.gov/pubmed/577471
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author Briand, P.
Thorpe, S. M.
Daehnfeldt, J. L.
author_facet Briand, P.
Thorpe, S. M.
Daehnfeldt, J. L.
author_sort Briand, P.
collection PubMed
description Administration of ovine prolactin alone supported growth of hormone-dependent GR mouse mammary tumours. Growth of hormone-independent tumours was not stimulated. Furthermore, administration of bromocriptine, a compound that inhibits release of prolactin from the pituitary gland, was shown to inhibit the growth of hormone-dependent tumours in animals receiving treatment with progesterone + oestrone. Administration of prolactin or bromocriptine to mice bearing tumours that grew independently of progesterone + oestrone treatment had no influence on tumour growth. We conclude that direct as well as indirect evidence has been found for the involvement of prolactin in the growth of transplanted, hormone-dependent GR mouse mammary tumours.
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spelling pubmed-20255232009-09-10 Effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours. Briand, P. Thorpe, S. M. Daehnfeldt, J. L. Br J Cancer Research Article Administration of ovine prolactin alone supported growth of hormone-dependent GR mouse mammary tumours. Growth of hormone-independent tumours was not stimulated. Furthermore, administration of bromocriptine, a compound that inhibits release of prolactin from the pituitary gland, was shown to inhibit the growth of hormone-dependent tumours in animals receiving treatment with progesterone + oestrone. Administration of prolactin or bromocriptine to mice bearing tumours that grew independently of progesterone + oestrone treatment had no influence on tumour growth. We conclude that direct as well as indirect evidence has been found for the involvement of prolactin in the growth of transplanted, hormone-dependent GR mouse mammary tumours. Nature Publishing Group 1977-06 /pmc/articles/PMC2025523/ /pubmed/577471 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Briand, P.
Thorpe, S. M.
Daehnfeldt, J. L.
Effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours.
title Effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours.
title_full Effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours.
title_fullStr Effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours.
title_full_unstemmed Effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours.
title_short Effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours.
title_sort effect of prolactin and bromocriptine on growth of transplanted hormone-dependent mouse mammary tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025523/
https://www.ncbi.nlm.nih.gov/pubmed/577471
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AT daehnfeldtjl effectofprolactinandbromocriptineongrowthoftransplantedhormonedependentmousemammarytumours

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