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Influence of milk source on transplantability of histocompatible mammary tumours in mice.
It is confirmed that C3H mammary tumours are much more easily transplantable in histocompatible recipients when these have been reared on C3H milk, than when they have been reared on milk from the inbred Swiss/B strain. By contrast, A.CA mammary tumours transplanted in histocompatible hosts reared o...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1977
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025536/ https://www.ncbi.nlm.nih.gov/pubmed/326285 |
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author | Oth, D. Sabolovic, D. |
author_facet | Oth, D. Sabolovic, D. |
author_sort | Oth, D. |
collection | PubMed |
description | It is confirmed that C3H mammary tumours are much more easily transplantable in histocompatible recipients when these have been reared on C3H milk, than when they have been reared on milk from the inbred Swiss/B strain. By contrast, A.CA mammary tumours transplanted in histocompatible hosts reared on A.CA or Swiss/B milk, grow almost equally well in both sorts of recipient. Thus, rearing on Swiss/B milk has different effects on the transplantability of mammary tumours of C3H and A.CA. On the other hand, recipients which were reared on C3H or A.CA milks accept grafts of C3H mammary tumours about equally, suggesting that milks from A.CA and C3H have the same effect on the transplantability of C3H mammary tumours. The different action of Swiss/B milk on tumours of C3H and A.CA seems best attributed to differences between C3H and A.CA tumours or between mouse strain genotypes. By contrast, the transplantability of C3H mammary tumours is significantly changed when the recipients were reared on milk from the RIII strain instead of C3H. These facts suggest that the milk from RIII has an action which differs from that of both C3H and A.CA in this respect. The data are discussed on the basis of a differential tollerance-inducing action of mammary tumour viruses (MTVs) which infect C3H, A.CA and RIII, and have an important role in tumour induction. |
format | Text |
id | pubmed-2025536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1977 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20255362009-09-10 Influence of milk source on transplantability of histocompatible mammary tumours in mice. Oth, D. Sabolovic, D. Br J Cancer Research Article It is confirmed that C3H mammary tumours are much more easily transplantable in histocompatible recipients when these have been reared on C3H milk, than when they have been reared on milk from the inbred Swiss/B strain. By contrast, A.CA mammary tumours transplanted in histocompatible hosts reared on A.CA or Swiss/B milk, grow almost equally well in both sorts of recipient. Thus, rearing on Swiss/B milk has different effects on the transplantability of mammary tumours of C3H and A.CA. On the other hand, recipients which were reared on C3H or A.CA milks accept grafts of C3H mammary tumours about equally, suggesting that milks from A.CA and C3H have the same effect on the transplantability of C3H mammary tumours. The different action of Swiss/B milk on tumours of C3H and A.CA seems best attributed to differences between C3H and A.CA tumours or between mouse strain genotypes. By contrast, the transplantability of C3H mammary tumours is significantly changed when the recipients were reared on milk from the RIII strain instead of C3H. These facts suggest that the milk from RIII has an action which differs from that of both C3H and A.CA in this respect. The data are discussed on the basis of a differential tollerance-inducing action of mammary tumour viruses (MTVs) which infect C3H, A.CA and RIII, and have an important role in tumour induction. Nature Publishing Group 1977-06 /pmc/articles/PMC2025536/ /pubmed/326285 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Oth, D. Sabolovic, D. Influence of milk source on transplantability of histocompatible mammary tumours in mice. |
title | Influence of milk source on transplantability of histocompatible mammary tumours in mice. |
title_full | Influence of milk source on transplantability of histocompatible mammary tumours in mice. |
title_fullStr | Influence of milk source on transplantability of histocompatible mammary tumours in mice. |
title_full_unstemmed | Influence of milk source on transplantability of histocompatible mammary tumours in mice. |
title_short | Influence of milk source on transplantability of histocompatible mammary tumours in mice. |
title_sort | influence of milk source on transplantability of histocompatible mammary tumours in mice. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025536/ https://www.ncbi.nlm.nih.gov/pubmed/326285 |
work_keys_str_mv | AT othd influenceofmilksourceontransplantabilityofhistocompatiblemammarytumoursinmice AT sabolovicd influenceofmilksourceontransplantabilityofhistocompatiblemammarytumoursinmice |