Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.

The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are...

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Detalles Bibliográficos
Autores principales: Hall, E. J., Astor, M., Geard, C., Biaglow, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025538/
https://www.ncbi.nlm.nih.gov/pubmed/871368
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author Hall, E. J.
Astor, M.
Geard, C.
Biaglow, J.
author_facet Hall, E. J.
Astor, M.
Geard, C.
Biaglow, J.
author_sort Hall, E. J.
collection PubMed
description The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01.
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spelling pubmed-20255382009-09-10 Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine. Hall, E. J. Astor, M. Geard, C. Biaglow, J. Br J Cancer Research Article The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01. Nature Publishing Group 1977-06 /pmc/articles/PMC2025538/ /pubmed/871368 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hall, E. J.
Astor, M.
Geard, C.
Biaglow, J.
Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
title Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
title_full Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
title_fullStr Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
title_full_unstemmed Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
title_short Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
title_sort cytotoxicity of ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025538/
https://www.ncbi.nlm.nih.gov/pubmed/871368
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AT geardc cytotoxicityofro070582enhancementbyhyperthermiaandprotectionbycysteamine
AT biaglowj cytotoxicityofro070582enhancementbyhyperthermiaandprotectionbycysteamine

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