Properties of a cell line from human adenocarcinoma of the rectum.

A new, highly differentiated line of cells derived from adenocarcinoma of the rectum (HT55) is described. This line is noteworthy for the following features: 1. The role played in its development by the use of UV-inactivated Sendai virus to attach tumour cell clumps to plastic bottles. 2. Evidence t...

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Detalles Bibliográficos
Autores principales: Watkins, J. F., Sanger, C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025539/
https://www.ncbi.nlm.nih.gov/pubmed/194617
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author Watkins, J. F.
Sanger, C.
author_facet Watkins, J. F.
Sanger, C.
author_sort Watkins, J. F.
collection PubMed
description A new, highly differentiated line of cells derived from adenocarcinoma of the rectum (HT55) is described. This line is noteworthy for the following features: 1. The role played in its development by the use of UV-inactivated Sendai virus to attach tumour cell clumps to plastic bottles. 2. Evidence that it produces RNA-containing material of density 1-5--1-16 g/ml. 3. Induction of bone formation in the stroma when grown in athymic mice. 4. Stimulation of primary CBA mouse embryo fibroblasts to form a transient nodule when mixed with them and injected into adult CBA mice. The karyotype and growth-cycle characteristics of the line are described. IMAGES:
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spelling pubmed-20255392009-09-10 Properties of a cell line from human adenocarcinoma of the rectum. Watkins, J. F. Sanger, C. Br J Cancer Research Article A new, highly differentiated line of cells derived from adenocarcinoma of the rectum (HT55) is described. This line is noteworthy for the following features: 1. The role played in its development by the use of UV-inactivated Sendai virus to attach tumour cell clumps to plastic bottles. 2. Evidence that it produces RNA-containing material of density 1-5--1-16 g/ml. 3. Induction of bone formation in the stroma when grown in athymic mice. 4. Stimulation of primary CBA mouse embryo fibroblasts to form a transient nodule when mixed with them and injected into adult CBA mice. The karyotype and growth-cycle characteristics of the line are described. IMAGES: Nature Publishing Group 1977-06 /pmc/articles/PMC2025539/ /pubmed/194617 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Watkins, J. F.
Sanger, C.
Properties of a cell line from human adenocarcinoma of the rectum.
title Properties of a cell line from human adenocarcinoma of the rectum.
title_full Properties of a cell line from human adenocarcinoma of the rectum.
title_fullStr Properties of a cell line from human adenocarcinoma of the rectum.
title_full_unstemmed Properties of a cell line from human adenocarcinoma of the rectum.
title_short Properties of a cell line from human adenocarcinoma of the rectum.
title_sort properties of a cell line from human adenocarcinoma of the rectum.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025539/
https://www.ncbi.nlm.nih.gov/pubmed/194617
work_keys_str_mv AT watkinsjf propertiesofacelllinefromhumanadenocarcinomaoftherectum
AT sangerc propertiesofacelllinefromhumanadenocarcinomaoftherectum

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