Detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease.

A simple rapid micro-agglutination test for detecting sensitized lymphocytes from human peripheral blood is described: the poly-L-lysine (PLL) 3400 agglutination test of lymphocytes (PAL test). The incubation of lymphocytes from 30 cancer patients, 30 patients with non-malignant disease and 40 healt...

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Detalles Bibliográficos
Autores principales: Bauer, H. W., Ax, W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025553/
https://www.ncbi.nlm.nih.gov/pubmed/597471
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author Bauer, H. W.
Ax, W.
author_facet Bauer, H. W.
Ax, W.
author_sort Bauer, H. W.
collection PubMed
description A simple rapid micro-agglutination test for detecting sensitized lymphocytes from human peripheral blood is described: the poly-L-lysine (PLL) 3400 agglutination test of lymphocytes (PAL test). The incubation of lymphocytes from 30 cancer patients, 30 patients with non-malignant disease and 40 healthy controls with PLL (mol. wt 3400) is evaluated. The test was positive in 83 percent of malignant and 20 percent of non-malignant cases. All healthy controls were negative. Other peptides tested showed no significant difference in reaction between malignant and non-malignant diseases. The mechanism of detection of sensitized lymphocytes from patients with malignant disease through agglutination induced by PLL 3400 is discussed. IMAGES:
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spelling pubmed-20255532009-09-10 Detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease. Bauer, H. W. Ax, W. Br J Cancer Research Article A simple rapid micro-agglutination test for detecting sensitized lymphocytes from human peripheral blood is described: the poly-L-lysine (PLL) 3400 agglutination test of lymphocytes (PAL test). The incubation of lymphocytes from 30 cancer patients, 30 patients with non-malignant disease and 40 healthy controls with PLL (mol. wt 3400) is evaluated. The test was positive in 83 percent of malignant and 20 percent of non-malignant cases. All healthy controls were negative. Other peptides tested showed no significant difference in reaction between malignant and non-malignant diseases. The mechanism of detection of sensitized lymphocytes from patients with malignant disease through agglutination induced by PLL 3400 is discussed. IMAGES: Nature Publishing Group 1977-12 /pmc/articles/PMC2025553/ /pubmed/597471 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bauer, H. W.
Ax, W.
Detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease.
title Detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease.
title_full Detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease.
title_fullStr Detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease.
title_full_unstemmed Detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease.
title_short Detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease.
title_sort detection of sensitized human blood lymphocytes by agglutination with basic peptides: a possible test for malignant disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025553/
https://www.ncbi.nlm.nih.gov/pubmed/597471
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