Enhancement by cytotoxic agents of artificial pulmonary metastasis.

The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before t...

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Detalles Bibliográficos
Autores principales: Steel, G. G., Adams, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025565/
https://www.ncbi.nlm.nih.gov/pubmed/74258
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author Steel, G. G.
Adams, K.
author_facet Steel, G. G.
Adams, K.
author_sort Steel, G. G.
collection PubMed
description The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells.
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spelling pubmed-20255652009-09-10 Enhancement by cytotoxic agents of artificial pulmonary metastasis. Steel, G. G. Adams, K. Br J Cancer Research Article The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells. Nature Publishing Group 1977-12 /pmc/articles/PMC2025565/ /pubmed/74258 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Steel, G. G.
Adams, K.
Enhancement by cytotoxic agents of artificial pulmonary metastasis.
title Enhancement by cytotoxic agents of artificial pulmonary metastasis.
title_full Enhancement by cytotoxic agents of artificial pulmonary metastasis.
title_fullStr Enhancement by cytotoxic agents of artificial pulmonary metastasis.
title_full_unstemmed Enhancement by cytotoxic agents of artificial pulmonary metastasis.
title_short Enhancement by cytotoxic agents of artificial pulmonary metastasis.
title_sort enhancement by cytotoxic agents of artificial pulmonary metastasis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025565/
https://www.ncbi.nlm.nih.gov/pubmed/74258
work_keys_str_mv AT steelgg enhancementbycytotoxicagentsofartificialpulmonarymetastasis
AT adamsk enhancementbycytotoxicagentsofartificialpulmonarymetastasis

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