Site-directed in vitro immunization leads to a complete human monoclonal IgG4λ that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands

BACKGROUND: The ability to acquire fully human monoclonal antibodies (mAbs) with pre-defined specificities is critical to the development of molecular tags for the analysis of receptor function in addition to promising immunotherapeutics. Yet most of the arriving affinity maturated and complete huma...

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Detalles Bibliográficos
Autores principales: Chin, Li-Te, Chu, Chishih, Chen, Han-Min, Hsu, Shu-Ching, Weng, Bor-Chun, Chu, Chi-Hong
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025598/
https://www.ncbi.nlm.nih.gov/pubmed/17714596
http://dx.doi.org/10.1186/1472-6750-7-51

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