Protection of Rhesus Monkeys by a DNA Prime/Poxvirus Boost Malaria Vaccine Depends on Optimal DNA Priming and Inclusion of Blood Stage Antigens

BACKGROUND: We have previously described a four antigen malaria vaccine consisting of DNA plasmids boosted by recombinant poxviruses which protects a high percentage of rhesus monkeys against Plasmodium knowlesi (Pk) malaria. This is a multi-stage vaccine that includes two pre-erythrocytic antigens,...

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Detalles Bibliográficos
Autores principales: Weiss, Walter R., Kumar, Anita, Jiang, George, Williams, Jackie, Bostick, Anthony, Conteh, Solomon, Fryauff, David, Aguiar, Joao, Singh, Manmohan, O'Hagan, Derek T., Ulmer, Jeffery B., Richie, Thomas L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2031826/
https://www.ncbi.nlm.nih.gov/pubmed/17957247
http://dx.doi.org/10.1371/journal.pone.0001063

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