Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.

The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this thera...

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Autores principales: Woodburn, K. W., Hill, J. S., Stylli, S., Kaye, A. H., Reiss, J. A., Phillips, D. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033371/
https://www.ncbi.nlm.nih.gov/pubmed/8080721
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author Woodburn, K. W.
Hill, J. S.
Stylli, S.
Kaye, A. H.
Reiss, J. A.
Phillips, D. R.
author_facet Woodburn, K. W.
Hill, J. S.
Stylli, S.
Kaye, A. H.
Reiss, J. A.
Phillips, D. R.
author_sort Woodburn, K. W.
collection PubMed
description The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.
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spelling pubmed-20333712009-09-10 Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy. Woodburn, K. W. Hill, J. S. Stylli, S. Kaye, A. H. Reiss, J. A. Phillips, D. R. Br J Cancer Research Article The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites. Nature Publishing Group 1994-09 /pmc/articles/PMC2033371/ /pubmed/8080721 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Woodburn, K. W.
Hill, J. S.
Stylli, S.
Kaye, A. H.
Reiss, J. A.
Phillips, D. R.
Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
title Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
title_full Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
title_fullStr Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
title_full_unstemmed Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
title_short Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
title_sort evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033371/
https://www.ncbi.nlm.nih.gov/pubmed/8080721
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