Delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline.

The relation between pretreatment night-time urinary catecholamine excretion and chemotherapy-induced nausea and vomiting was studied. The first cohort included 17 women and three men with various cancer forms receiving low or moderately emetogenic chemotherapy. The second cohort included 42 women r...

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Autores principales: Fredrikson, M., Hursti, T. J., Steineck, G., Fürst, C. J., Börjesson, S., Peterson, C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033385/
https://www.ncbi.nlm.nih.gov/pubmed/7917910
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author Fredrikson, M.
Hursti, T. J.
Steineck, G.
Fürst, C. J.
Börjesson, S.
Peterson, C.
author_facet Fredrikson, M.
Hursti, T. J.
Steineck, G.
Fürst, C. J.
Börjesson, S.
Peterson, C.
author_sort Fredrikson, M.
collection PubMed
description The relation between pretreatment night-time urinary catecholamine excretion and chemotherapy-induced nausea and vomiting was studied. The first cohort included 17 women and three men with various cancer forms receiving low or moderately emetogenic chemotherapy. The second cohort included 42 women receiving cisplatinum (50 mg m-2) for ovarian cancer and ondansetron as an antiemetic (8 mg i.v. x 3 at chemotherapy and 8 mg p.o. x 3 for 5 days). Relatively higher noradrenaline, but not adrenaline, excretion was associated with an increased intensity of delayed nausea following treatment. Vomiting was not consistently related to the excretion of either catecholamine. The results indicate that noradrenaline modulates delayed nausea resulting from chemotherapy.
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spelling pubmed-20333852009-09-10 Delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline. Fredrikson, M. Hursti, T. J. Steineck, G. Fürst, C. J. Börjesson, S. Peterson, C. Br J Cancer Research Article The relation between pretreatment night-time urinary catecholamine excretion and chemotherapy-induced nausea and vomiting was studied. The first cohort included 17 women and three men with various cancer forms receiving low or moderately emetogenic chemotherapy. The second cohort included 42 women receiving cisplatinum (50 mg m-2) for ovarian cancer and ondansetron as an antiemetic (8 mg i.v. x 3 at chemotherapy and 8 mg p.o. x 3 for 5 days). Relatively higher noradrenaline, but not adrenaline, excretion was associated with an increased intensity of delayed nausea following treatment. Vomiting was not consistently related to the excretion of either catecholamine. The results indicate that noradrenaline modulates delayed nausea resulting from chemotherapy. Nature Publishing Group 1994-10 /pmc/articles/PMC2033385/ /pubmed/7917910 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Fredrikson, M.
Hursti, T. J.
Steineck, G.
Fürst, C. J.
Börjesson, S.
Peterson, C.
Delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline.
title Delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline.
title_full Delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline.
title_fullStr Delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline.
title_full_unstemmed Delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline.
title_short Delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline.
title_sort delayed chemotherapy-induced nausea is augmented by high levels of endogenous noradrenaline.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033385/
https://www.ncbi.nlm.nih.gov/pubmed/7917910
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