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5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.

In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the inc...

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Autores principales: Jebb, S. A., Osborne, R. J., Maughan, T. S., Mohideen, N., Mack, P., Mort, D., Shelley, M. D., Elia, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033386/
https://www.ncbi.nlm.nih.gov/pubmed/7917930
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author Jebb, S. A.
Osborne, R. J.
Maughan, T. S.
Mohideen, N.
Mack, P.
Mort, D.
Shelley, M. D.
Elia, M.
author_facet Jebb, S. A.
Osborne, R. J.
Maughan, T. S.
Mohideen, N.
Mack, P.
Mort, D.
Shelley, M. D.
Elia, M.
author_sort Jebb, S. A.
collection PubMed
description In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity of cytotoxic-induced mucositis. This study examined the role of oral glutamine supplementation in the management of mucositis caused by 5-fluorouracil (5-FU) and folinic acid. Twenty-eight patients with gastrointestinal cancers were randomised to receive 16 g of glutamine per day for 8 days, or placebo, in a randomised double-blind trial before crossing over to the alternative supplement during the second treatment cycle. The supplement was well tolerated with no apparent adverse effects, but failed to have any significant effect on oral mucositis assessed by the patients or investigator. The possible reasons for this apparent lack of benefit are discussed.
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spelling pubmed-20333862009-09-10 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. Jebb, S. A. Osborne, R. J. Maughan, T. S. Mohideen, N. Mack, P. Mort, D. Shelley, M. D. Elia, M. Br J Cancer Research Article In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity of cytotoxic-induced mucositis. This study examined the role of oral glutamine supplementation in the management of mucositis caused by 5-fluorouracil (5-FU) and folinic acid. Twenty-eight patients with gastrointestinal cancers were randomised to receive 16 g of glutamine per day for 8 days, or placebo, in a randomised double-blind trial before crossing over to the alternative supplement during the second treatment cycle. The supplement was well tolerated with no apparent adverse effects, but failed to have any significant effect on oral mucositis assessed by the patients or investigator. The possible reasons for this apparent lack of benefit are discussed. Nature Publishing Group 1994-10 /pmc/articles/PMC2033386/ /pubmed/7917930 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jebb, S. A.
Osborne, R. J.
Maughan, T. S.
Mohideen, N.
Mack, P.
Mort, D.
Shelley, M. D.
Elia, M.
5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
title 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
title_full 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
title_fullStr 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
title_full_unstemmed 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
title_short 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
title_sort 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033386/
https://www.ncbi.nlm.nih.gov/pubmed/7917930
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