Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs.

The cytotoxic potency of 4-alkylamino-5-nitroquinoline drugs in AA8 cell cultures is enhanced up to 60-fold under hypoxia, with wide variations in selectivity for hypoxic cells observed for different members of this series. This study uses three representative 5-nitroquinolines to examine whether th...

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Detalles Bibliográficos
Autores principales: Siim, B. G., Atwell, G. J., Wilson, W. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033401/
https://www.ncbi.nlm.nih.gov/pubmed/7917903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033401/
https://www.ncbi.nlm.nih.gov/pubmed/7917903

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