O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.

Tumour samples obtained from one primary melanoma and several lymph node and skin metastases were analysed for O6-methylguanine-DNA methyltransferase (MGMT) activity. While lymph node and skin metastases had similar average MGMT activity, the variance was significantly higher in lymph node metastase...

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Detalles Bibliográficos
Autores principales: Egyházi, S., Hansson, J., Ringborg, U.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033437/
https://www.ncbi.nlm.nih.gov/pubmed/7819045
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author Egyházi, S.
Hansson, J.
Ringborg, U.
author_facet Egyházi, S.
Hansson, J.
Ringborg, U.
author_sort Egyházi, S.
collection PubMed
description Tumour samples obtained from one primary melanoma and several lymph node and skin metastases were analysed for O6-methylguanine-DNA methyltransferase (MGMT) activity. While lymph node and skin metastases had similar average MGMT activity, the variance was significantly higher in lymph node metastases. Variability in MGMT activity was frequently observed in different metastases in the same individual and to a lesser extent within metastases.
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spelling pubmed-20334372009-09-10 O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours. Egyházi, S. Hansson, J. Ringborg, U. Br J Cancer Research Article Tumour samples obtained from one primary melanoma and several lymph node and skin metastases were analysed for O6-methylguanine-DNA methyltransferase (MGMT) activity. While lymph node and skin metastases had similar average MGMT activity, the variance was significantly higher in lymph node metastases. Variability in MGMT activity was frequently observed in different metastases in the same individual and to a lesser extent within metastases. Nature Publishing Group 1995-01 /pmc/articles/PMC2033437/ /pubmed/7819045 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Egyházi, S.
Hansson, J.
Ringborg, U.
O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
title O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
title_full O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
title_fullStr O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
title_full_unstemmed O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
title_short O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
title_sort o6-methylguanine-dna methyltransferase activities in biopsies of human melanoma tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033437/
https://www.ncbi.nlm.nih.gov/pubmed/7819045
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