An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.

Meta-analysis of the published results from 54 randomised controlled trials of adjuvant chemotherapy in head and neck cancer suggests that chemotherapy might increase absolute survival by 6.5% (95% confidence interval 3.1-9.9%). The odds ratio in favour of chemotherapy is 1.37 (95% confidence interv...

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Autor principal: Munro, A. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033467/
https://www.ncbi.nlm.nih.gov/pubmed/7819055
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author Munro, A. J.
author_facet Munro, A. J.
author_sort Munro, A. J.
collection PubMed
description Meta-analysis of the published results from 54 randomised controlled trials of adjuvant chemotherapy in head and neck cancer suggests that chemotherapy might increase absolute survival by 6.5% (95% confidence interval 3.1-9.9%). The odds ratio in favour of chemotherapy is 1.37 (95% confidence interval 1.24-1.5). Single-agent chemotherapy given synchronously with radiotherapy increased survival by 12.1% (95% confidence interval 5-19%). The benefit from neoadjuvant chemotherapy was less: a rate difference of 3.7% (95% confidence interval 0.9-6.5%). The results suggest that the investigation of optimal agents and scheduling for synchronous radiotherapy and chemotherapy might still be important in clinical trials in head and neck cancer.
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spelling pubmed-20334672009-09-10 An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer. Munro, A. J. Br J Cancer Research Article Meta-analysis of the published results from 54 randomised controlled trials of adjuvant chemotherapy in head and neck cancer suggests that chemotherapy might increase absolute survival by 6.5% (95% confidence interval 3.1-9.9%). The odds ratio in favour of chemotherapy is 1.37 (95% confidence interval 1.24-1.5). Single-agent chemotherapy given synchronously with radiotherapy increased survival by 12.1% (95% confidence interval 5-19%). The benefit from neoadjuvant chemotherapy was less: a rate difference of 3.7% (95% confidence interval 0.9-6.5%). The results suggest that the investigation of optimal agents and scheduling for synchronous radiotherapy and chemotherapy might still be important in clinical trials in head and neck cancer. Nature Publishing Group 1995-01 /pmc/articles/PMC2033467/ /pubmed/7819055 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Munro, A. J.
An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.
title An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.
title_full An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.
title_fullStr An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.
title_full_unstemmed An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.
title_short An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.
title_sort overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033467/
https://www.ncbi.nlm.nih.gov/pubmed/7819055
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