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Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.

The expression of tumour necrosis factor alpha (TNF-alpha) and its two distinct receptors, TNF-R p55 and TNF-R p75, was assessed by immunocytochemistry in 28 primary breast cancer and three reduction mammoplasty specimens ('normal' breast tissue). Expression of TNF-alpha or TNF-R p75 was n...

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Autores principales: Pusztai, L., Clover, L. M., Cooper, K., Starkey, P. M., Lewis, C. E., McGee, J. O.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033509/
https://www.ncbi.nlm.nih.gov/pubmed/7519867
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author Pusztai, L.
Clover, L. M.
Cooper, K.
Starkey, P. M.
Lewis, C. E.
McGee, J. O.
author_facet Pusztai, L.
Clover, L. M.
Cooper, K.
Starkey, P. M.
Lewis, C. E.
McGee, J. O.
author_sort Pusztai, L.
collection PubMed
description The expression of tumour necrosis factor alpha (TNF-alpha) and its two distinct receptors, TNF-R p55 and TNF-R p75, was assessed by immunocytochemistry in 28 primary breast cancer and three reduction mammoplasty specimens ('normal' breast tissue). Expression of TNF-alpha or TNF-R p75 was not detectable in normal breast tissue or in non-malignant breast tissue adjacent to the tumours. By contrast, TNF-R p55 was expressed by occasional stromal cells in normal tissue. TNF-alpha was expressed focally in 50% of the tumours studied, being largely localised to macrophage-like cells in the stroma. TNF-R p55 was expressed by a population of stromal cells in all the tumours examined, and a varying proportion of neoplastic cells in 75% of these tissues. TNF-R p75 was detected in about 70% of the tumours, immunoreactivity being confined mainly to cells in the stroma. In this preliminary study there was no association between the above cytokine parameters and such measures of tumour biology as lymph node status, tumour grade, proliferative activity or degree of angiogenesis. However, there was a correlation between the expression of TNF-R p55 by blood vessels and the number of leucocytes present. IMAGES:
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spelling pubmed-20335092009-09-10 Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast. Pusztai, L. Clover, L. M. Cooper, K. Starkey, P. M. Lewis, C. E. McGee, J. O. Br J Cancer Research Article The expression of tumour necrosis factor alpha (TNF-alpha) and its two distinct receptors, TNF-R p55 and TNF-R p75, was assessed by immunocytochemistry in 28 primary breast cancer and three reduction mammoplasty specimens ('normal' breast tissue). Expression of TNF-alpha or TNF-R p75 was not detectable in normal breast tissue or in non-malignant breast tissue adjacent to the tumours. By contrast, TNF-R p55 was expressed by occasional stromal cells in normal tissue. TNF-alpha was expressed focally in 50% of the tumours studied, being largely localised to macrophage-like cells in the stroma. TNF-R p55 was expressed by a population of stromal cells in all the tumours examined, and a varying proportion of neoplastic cells in 75% of these tissues. TNF-R p75 was detected in about 70% of the tumours, immunoreactivity being confined mainly to cells in the stroma. In this preliminary study there was no association between the above cytokine parameters and such measures of tumour biology as lymph node status, tumour grade, proliferative activity or degree of angiogenesis. However, there was a correlation between the expression of TNF-R p55 by blood vessels and the number of leucocytes present. IMAGES: Nature Publishing Group 1994-08 /pmc/articles/PMC2033509/ /pubmed/7519867 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pusztai, L.
Clover, L. M.
Cooper, K.
Starkey, P. M.
Lewis, C. E.
McGee, J. O.
Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
title Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
title_full Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
title_fullStr Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
title_full_unstemmed Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
title_short Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
title_sort expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033509/
https://www.ncbi.nlm.nih.gov/pubmed/7519867
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