Cargando…

Effects of 4-hydroxytamoxifen and a novel pure antioestrogen (ICI 182780) on the clonogenic growth of human breast cancer cells in vitro.

We have investigated the effects on breast cancer cell growth of 4-hydroxytamoxifen (4OHT), a conventional antioestrogen with agonist activity, and 7 alpha-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra- 1,3,5,(10)- triene-3,17 beta-diol (ICI 182780), a novel, pure antioestrogen, using establ...

Descripción completa

Detalles Bibliográficos
Autores principales:	DeFriend, D. J., Anderson, E., Bell, J., Wilks, D. P., West, C. M., Mansel, R. E., Howell, A.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1994
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033516/ https://www.ncbi.nlm.nih.gov/pubmed/8054267

Ejemplares similares

Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer.
por: Howell, A., et al.
Publicado: (1996)

Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells
por: Okubo, S, et al.
Publicado: (2004)

ICI 182,780 (Fulvestrant™) – the first oestrogen receptor down-regulator – current clinical data
por: Robertson, J F R
Publicado: (2001)

Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testosterone and ICI 182,780 sensitive mechanism
por: Kendall, Sherie L, et al.
Publicado: (2005)

A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780
por: Rabaglino, Maria Belen, et al.
Publicado: (2018)

Reduction of post injury neointima formation due to 17β-estradiol and phytoestrogen treatment is not influenced by the pure synthetic estrogen receptor antagonist ICI 182,780 in vitro
por: Finking, Gerald, et al.
Publicado: (2002)

ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis
por: Pinto, Patrícia IS, et al.
Publicado: (2006)

Effects of ICI 182780 on estrogen receptor expression, fluid absorption and sperm motility in the epididymis of the bonnet monkey
por: Shayu, Deshpande, et al.
Publicado: (2005)

Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines
por: Woode, Denzel R., et al.
Publicado: (2012)

Non-Steroidal Antioestrogens
por: Barnes, D.
Publicado: (1983)

Differential regulation of specific genes in MCF-7 and the ICI 182780-resistant cell line MCF-7/182(R)-6
por: Jensen, B L, et al.
Publicado: (1999)

ICI 182,780 Attenuates Selective Upregulation of Uterine Artery Cystathionine β-Synthase Expression in Rat Pregnancy
por: Bai, Jin, et al.
Publicado: (2023)

17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes
por: Jallow, Fatou, et al.
Publicado: (2018)

Endocrinology and hormone therapy in breast cancer: Aromatase inhibitors versus antioestrogens
por: Howell, Anthony, et al.
Publicado: (2004)

Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells
por: Muler, Mari Luminosa, et al.
Publicado: (2020)

Influence of the antioestrogen tamoxifen on normal breast tissue.
por: Walker, K. J., et al.
Publicado: (1991)

The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy
por: Cho, Hyun Wook, et al.
Publicado: (2003)

The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules
por: Oliveira, Cleida A, et al.
Publicado: (2003)

BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib
por: Godinho, M F E, et al.
Publicado: (2012)

On the Mechanism of Membrane Permeabilization by Tamoxifen and 4-Hydroxytamoxifen
por: Ortiz, Julia, et al.
Publicado: (2023)

Preventive effects of antioestrogen on mammary and pituitary tumorigenesis in rats.
por: Sumi, C., et al.
Publicado: (1984)

The anti-estrogen ICI 182,780, but not tamoxifen, inhibits the growth of MCF7 breast cancer cells refractory to long-term estrogen deprivation through downregulation of ER and IGF signalling
por: Martin, L-A, et al.
Publicado: (2005)

Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes
por: Ransom, Ryan C., et al.
Publicado: (2018)

First-line endocrine treatment of breast cancer: aromatase inhibitor or antioestrogen?
por: Wong, Z-W, et al.
Publicado: (2004)

Regulated control of virus replication by 4-hydroxytamoxifen-induced splicing
por: Zhao, Zhenghao, et al.
Publicado: (2023)

Author Correction: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes
por: Ransom, Ryan C., et al.
Publicado: (2018)

Effects of the antioestrogen tamoxifen on the cell cycle kinetics of the human breast cancer cell line, MCF-7.
por: Lykkesfeldt, A. E., et al.
Publicado: (1984)

Prospective study on gynaecological effects of two antioestrogens tamoxifen and toremifene in postmenopausal women
por: Marttunen, M B, et al.
Publicado: (2001)

Radiation-induced micronuclei in human fibroblasts in relation to clonogenic radiosensitivity.
por: O'Driscoll, M. C., et al.
Publicado: (1998)

In Vitro Effects of Oestrogens, Antioestrogens and SERMs on Pancreatic Solid Pseudopapillary Neoplasm-Derived Primary Cell Culture
por: Tognarini, Isabella, et al.
Publicado: (2010)

The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer
por: Saarto, T, et al.
Publicado: (2001)

Loss of oestrogen receptor alpha in long-term antioestrogen-resistant cells: reversal by a c-src inhibitor
por: Bensmail, A, et al.
Publicado: (2008)

Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity
por: Howell, Sacha J, et al.
Publicado: (2008)

Direct, Differential Effects of Tamoxifen, 4-Hydroxytamoxifen, and Raloxifene on Cardiac Myocyte Contractility and Calcium Handling
por: Asp, Michelle L., et al.
Publicado: (2013)

ICIS05 CONFERENCE
por: Lau, C, et al.
Publicado: (02/1)

Clodronate improves bone mineral density in post-menopausal breast cancer patients treated with adjuvant antioestrogens.
por: Saarto, T., et al.
Publicado: (1997)

Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants
por: Sun, Dongxiao, et al.
Publicado: (2006)

Transporting Antitumor Drug Tamoxifen and Its Metabolites, 4-Hydroxytamoxifen and Endoxifen by Chitosan Nanoparticles
por: Agudelo, Daniel, et al.
Publicado: (2013)

No effect on pharmacokinetics of tamoxifen and 4-hydroxytamoxifen by multiple doses of red clover capsule in rats
por: Raju, Kanumuri Siva Rama, et al.
Publicado: (2015)

GSK5182, 4-Hydroxytamoxifen Analog, a New Potential Therapeutic Drug for Osteoarthritis
por: Min, Yunhui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vorls0udgf5h48l2n8r8j29d43