Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.

As an approach to the rational design of combination chemotherapy involving the anti-cancer DNA topoisomerase II poison etoposide (VP-16), we have studied the dynamic changes occurring in small-cell lung cancer (SCLC) cell populations during protracted VP-16 exposure. Cytometric methods were used to...

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Detalles Bibliográficos
Autores principales: Smith, P. J., Souès, S., Gottlieb, T., Falk, S. J., Watson, J. V., Osborne, R. J., Bleehen, N. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033529/
https://www.ncbi.nlm.nih.gov/pubmed/7947097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033529/
https://www.ncbi.nlm.nih.gov/pubmed/7947097

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