Identification of glioma-associated antigen MUC 2-63 as CD44.

Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in...

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Autores principales: Romeijn, P., Lenthall, R., Stavrou, D., Melcher, D., Ladyman, H., Ritter, M. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033549/
https://www.ncbi.nlm.nih.gov/pubmed/7524600
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author Romeijn, P.
Lenthall, R.
Stavrou, D.
Melcher, D.
Ladyman, H.
Ritter, M. A.
author_facet Romeijn, P.
Lenthall, R.
Stavrou, D.
Melcher, D.
Ladyman, H.
Ritter, M. A.
author_sort Romeijn, P.
collection PubMed
description Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies using MUC 2-63 and the CD44 anti-framework antibody F10-44-2. Thus not only MUC 2-63 but also other anti-CD44 monoclonal antibodies should prove useful in imaging and, perhaps, therapy of brain tumours. IMAGES:
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spelling pubmed-20335492009-09-10 Identification of glioma-associated antigen MUC 2-63 as CD44. Romeijn, P. Lenthall, R. Stavrou, D. Melcher, D. Ladyman, H. Ritter, M. A. Br J Cancer Research Article Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies using MUC 2-63 and the CD44 anti-framework antibody F10-44-2. Thus not only MUC 2-63 but also other anti-CD44 monoclonal antibodies should prove useful in imaging and, perhaps, therapy of brain tumours. IMAGES: Nature Publishing Group 1994-11 /pmc/articles/PMC2033549/ /pubmed/7524600 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Romeijn, P.
Lenthall, R.
Stavrou, D.
Melcher, D.
Ladyman, H.
Ritter, M. A.
Identification of glioma-associated antigen MUC 2-63 as CD44.
title Identification of glioma-associated antigen MUC 2-63 as CD44.
title_full Identification of glioma-associated antigen MUC 2-63 as CD44.
title_fullStr Identification of glioma-associated antigen MUC 2-63 as CD44.
title_full_unstemmed Identification of glioma-associated antigen MUC 2-63 as CD44.
title_short Identification of glioma-associated antigen MUC 2-63 as CD44.
title_sort identification of glioma-associated antigen muc 2-63 as cd44.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033549/
https://www.ncbi.nlm.nih.gov/pubmed/7524600
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