Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.

High levels of IL-6 were found in 50% of 114 patients with primary ovarian cancer. IL-6 sensitivity was lower than that of CA 125, and the combination of both assays did not increase the sensitivity of CA 125 alone. However, elevated IL-6 serum levels were correlated with a poor prognosis since pati...

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Autores principales: Scambia, G., Testa, U., Benedetti Panici, P., Foti, E., Martucci, R., Gadducci, A., Perillo, A., Facchini, V., Peschle, C., Mancuso, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033591/
https://www.ncbi.nlm.nih.gov/pubmed/7841052
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author Scambia, G.
Testa, U.
Benedetti Panici, P.
Foti, E.
Martucci, R.
Gadducci, A.
Perillo, A.
Facchini, V.
Peschle, C.
Mancuso, S.
author_facet Scambia, G.
Testa, U.
Benedetti Panici, P.
Foti, E.
Martucci, R.
Gadducci, A.
Perillo, A.
Facchini, V.
Peschle, C.
Mancuso, S.
author_sort Scambia, G.
collection PubMed
description High levels of IL-6 were found in 50% of 114 patients with primary ovarian cancer. IL-6 sensitivity was lower than that of CA 125, and the combination of both assays did not increase the sensitivity of CA 125 alone. However, elevated IL-6 serum levels were correlated with a poor prognosis since patients with low IL-6 levels had a better survival than patients with high IL-6 levels (P = 0.0009). Multivariate analysis revealed that IL-6 positivity has an independent value.
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spelling pubmed-20335912009-09-10 Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer. Scambia, G. Testa, U. Benedetti Panici, P. Foti, E. Martucci, R. Gadducci, A. Perillo, A. Facchini, V. Peschle, C. Mancuso, S. Br J Cancer Research Article High levels of IL-6 were found in 50% of 114 patients with primary ovarian cancer. IL-6 sensitivity was lower than that of CA 125, and the combination of both assays did not increase the sensitivity of CA 125 alone. However, elevated IL-6 serum levels were correlated with a poor prognosis since patients with low IL-6 levels had a better survival than patients with high IL-6 levels (P = 0.0009). Multivariate analysis revealed that IL-6 positivity has an independent value. Nature Publishing Group 1995-02 /pmc/articles/PMC2033591/ /pubmed/7841052 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Scambia, G.
Testa, U.
Benedetti Panici, P.
Foti, E.
Martucci, R.
Gadducci, A.
Perillo, A.
Facchini, V.
Peschle, C.
Mancuso, S.
Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
title Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
title_full Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
title_fullStr Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
title_full_unstemmed Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
title_short Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
title_sort prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033591/
https://www.ncbi.nlm.nih.gov/pubmed/7841052
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