Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.

A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviv...

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Detalles Bibliográficos
Autores principales: Dorudi, S., Hanby, A. M., Poulsom, R., Northover, J., Hart, I. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033614/
https://www.ncbi.nlm.nih.gov/pubmed/7880746
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author Dorudi, S.
Hanby, A. M.
Poulsom, R.
Northover, J.
Hart, I. R.
author_facet Dorudi, S.
Hanby, A. M.
Poulsom, R.
Northover, J.
Hart, I. R.
author_sort Dorudi, S.
collection PubMed
description A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients. IMAGES:
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spelling pubmed-20336142009-09-10 Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Dorudi, S. Hanby, A. M. Poulsom, R. Northover, J. Hart, I. R. Br J Cancer Research Article A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients. IMAGES: Nature Publishing Group 1995-03 /pmc/articles/PMC2033614/ /pubmed/7880746 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Dorudi, S.
Hanby, A. M.
Poulsom, R.
Northover, J.
Hart, I. R.
Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
title Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
title_full Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
title_fullStr Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
title_full_unstemmed Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
title_short Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
title_sort level of expression of e-cadherin mrna in colorectal cancer correlates with clinical outcome.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033614/
https://www.ncbi.nlm.nih.gov/pubmed/7880746
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AT northoverj levelofexpressionofecadherinmrnaincolorectalcancercorrelateswithclinicaloutcome
AT hartir levelofexpressionofecadherinmrnaincolorectalcancercorrelateswithclinicaloutcome

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