The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.

In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol...

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Autores principales: Nygren, P., Csoka, K., Jonsson, B., Fridborg, H., Bergh, J., Hagberg, H., Glimelius, B., Brodin, O., Tholander, B., Kreuger, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033622/
https://www.ncbi.nlm.nih.gov/pubmed/7880727
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author Nygren, P.
Csoka, K.
Jonsson, B.
Fridborg, H.
Bergh, J.
Hagberg, H.
Glimelius, B.
Brodin, O.
Tholander, B.
Kreuger, A.
author_facet Nygren, P.
Csoka, K.
Jonsson, B.
Fridborg, H.
Bergh, J.
Hagberg, H.
Glimelius, B.
Brodin, O.
Tholander, B.
Kreuger, A.
author_sort Nygren, P.
collection PubMed
description In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active. Taxol thus seems to contain two components active against patient tumour cells in vitro.
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spelling pubmed-20336222009-09-10 The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL. Nygren, P. Csoka, K. Jonsson, B. Fridborg, H. Bergh, J. Hagberg, H. Glimelius, B. Brodin, O. Tholander, B. Kreuger, A. Br J Cancer Research Article In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active. Taxol thus seems to contain two components active against patient tumour cells in vitro. Nature Publishing Group 1995-03 /pmc/articles/PMC2033622/ /pubmed/7880727 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Nygren, P.
Csoka, K.
Jonsson, B.
Fridborg, H.
Bergh, J.
Hagberg, H.
Glimelius, B.
Brodin, O.
Tholander, B.
Kreuger, A.
The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.
title The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.
title_full The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.
title_fullStr The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.
title_full_unstemmed The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.
title_short The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.
title_sort cytotoxic activity of taxol in primary cultures of tumour cells from patients is partly mediated by cremophor el.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033622/
https://www.ncbi.nlm.nih.gov/pubmed/7880727
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