Loss of heterozygosity of the oestrogen receptor gene in breast cancer.

DNA from 67 primary breast carcinoma biopsies has been examined for loss of heterozygosity (LOH) using the microsatellite (TA)n repeat marker positioned 1 kb upstream of the oestrogen receptor (ER) gene. Forty-seven (70.1%) of the cases were informative; nine of these (19.1%) were positive for LOH....

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Autores principales: Iwase, H., Greenman, J. M., Barnes, D. M., Bobrow, L., Hodgson, S., Mathew, C. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033633/
https://www.ncbi.nlm.nih.gov/pubmed/7880722
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author Iwase, H.
Greenman, J. M.
Barnes, D. M.
Bobrow, L.
Hodgson, S.
Mathew, C. G.
author_facet Iwase, H.
Greenman, J. M.
Barnes, D. M.
Bobrow, L.
Hodgson, S.
Mathew, C. G.
author_sort Iwase, H.
collection PubMed
description DNA from 67 primary breast carcinoma biopsies has been examined for loss of heterozygosity (LOH) using the microsatellite (TA)n repeat marker positioned 1 kb upstream of the oestrogen receptor (ER) gene. Forty-seven (70.1%) of the cases were informative; nine of these (19.1%) were positive for LOH. In three of the nine cases, there was total loss, and in the other six cases there was a marked reduction in the intensity of signal from one allele. LOH correlated weakly with histological grade and age, but not with ER status. This result suggests that LOH of the ER gene does not have an important role in the lack of ER function in breast cancer tissues. IMAGES:
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spelling pubmed-20336332009-09-10 Loss of heterozygosity of the oestrogen receptor gene in breast cancer. Iwase, H. Greenman, J. M. Barnes, D. M. Bobrow, L. Hodgson, S. Mathew, C. G. Br J Cancer Research Article DNA from 67 primary breast carcinoma biopsies has been examined for loss of heterozygosity (LOH) using the microsatellite (TA)n repeat marker positioned 1 kb upstream of the oestrogen receptor (ER) gene. Forty-seven (70.1%) of the cases were informative; nine of these (19.1%) were positive for LOH. In three of the nine cases, there was total loss, and in the other six cases there was a marked reduction in the intensity of signal from one allele. LOH correlated weakly with histological grade and age, but not with ER status. This result suggests that LOH of the ER gene does not have an important role in the lack of ER function in breast cancer tissues. IMAGES: Nature Publishing Group 1995-03 /pmc/articles/PMC2033633/ /pubmed/7880722 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Iwase, H.
Greenman, J. M.
Barnes, D. M.
Bobrow, L.
Hodgson, S.
Mathew, C. G.
Loss of heterozygosity of the oestrogen receptor gene in breast cancer.
title Loss of heterozygosity of the oestrogen receptor gene in breast cancer.
title_full Loss of heterozygosity of the oestrogen receptor gene in breast cancer.
title_fullStr Loss of heterozygosity of the oestrogen receptor gene in breast cancer.
title_full_unstemmed Loss of heterozygosity of the oestrogen receptor gene in breast cancer.
title_short Loss of heterozygosity of the oestrogen receptor gene in breast cancer.
title_sort loss of heterozygosity of the oestrogen receptor gene in breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033633/
https://www.ncbi.nlm.nih.gov/pubmed/7880722
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