Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?

The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients....

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Autores principales: Hietanen, P., Blomqvist, C., Wasenius, V. M., Niskanen, E., Franssila, K., Nordling, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033766/
https://www.ncbi.nlm.nih.gov/pubmed/7734295
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author Hietanen, P.
Blomqvist, C.
Wasenius, V. M.
Niskanen, E.
Franssila, K.
Nordling, S.
author_facet Hietanen, P.
Blomqvist, C.
Wasenius, V. M.
Niskanen, E.
Franssila, K.
Nordling, S.
author_sort Hietanen, P.
collection PubMed
description The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients. The response to chemotherapy was significantly better in patients with tumours with a high SPF, and in addition the time to progression was longer in the high-SPF group. There was no significant difference when the DNA ploidy and response to treatment were compared.
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spelling pubmed-20337662009-09-10 Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer? Hietanen, P. Blomqvist, C. Wasenius, V. M. Niskanen, E. Franssila, K. Nordling, S. Br J Cancer Research Article The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients. The response to chemotherapy was significantly better in patients with tumours with a high SPF, and in addition the time to progression was longer in the high-SPF group. There was no significant difference when the DNA ploidy and response to treatment were compared. Nature Publishing Group 1995-05 /pmc/articles/PMC2033766/ /pubmed/7734295 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hietanen, P.
Blomqvist, C.
Wasenius, V. M.
Niskanen, E.
Franssila, K.
Nordling, S.
Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?
title Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?
title_full Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?
title_fullStr Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?
title_full_unstemmed Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?
title_short Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?
title_sort do dna ploidy and s-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033766/
https://www.ncbi.nlm.nih.gov/pubmed/7734295
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