Cargando…

Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency.

This study was conducted to increase the anti-tumour potency and reduce the toxic side-effects of tumour necrosis factor alpha (TNF-alpha). Natural human TNF-alpha was chemically conjugated with monomethoxy polyethylene glycol (PEG) using succinimidyl coupling of lysine amino groups of TNF-alpha. Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsutsumi, Y., Kihira, T., Tsunoda, S., Kanamori, T., Nakagawa, S., Mayumi, T.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1995
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033790/ https://www.ncbi.nlm.nih.gov/pubmed/7734321

Ejemplares similares

Molecular design of hybrid tumour necrosis factor-alpha. II: The molecular size of polyethylene glycol-modified tumour necrosis factor-alpha affects its anti-tumour potency.
por: Tsutsumi, Y., et al.
Publicado: (1996)

Chemical Modification of Natural Human Tumor Necrosis Factor‐α with Polyethylene Glycol Increases Its Anti‐tumor Potency
por: Tsutsumi, Yasuo, et al.
Publicado: (1994)

In vivo Anti‐tumor Efficacy of Polyethylene Glycol‐modified Tumor Necrosis Factor‐α against Tumor Necrosis Factor‐resistant Tumors
por: Tsutsumi, Yasuo, et al.
Publicado: (1996)

Intravenous Administration of Polyethylene Glycol‐modified Tumor Necrosis Factor‐α Completely Regressed Solid Tumor in Meth‐A Murine Sarcoma Model
por: Tsutsumi, Yasuo, et al.
Publicado: (1994)

Polyethylene glycol modification of a galactosylated streptavidin clearing agent: effects on immunogenicity and clearance of a biotinylated anti-tumour antibody.
por: Marshall, D., et al.
Publicado: (1996)

Metabolic effects of tumour necrosis factor alpha in NMRI mice.
por: Mahony, S. M., et al.
Publicado: (1990)

Thermal enhancement of both tumour necrosis factor alpha-induced systemic toxicity and tumour cure in rats.
por: van der Zee, J., et al.
Publicado: (1995)

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
por: de Wilt, J H W, et al.
Publicado: (2000)

Anti-tumour necrosis factor alpha treatment in patients affected by rheumatoid arthritis with anti-Ro/SSA antibodies
por: Cavazzana, I, et al.
Publicado: (2005)

Interleukin 1 and tumour necrosis factor alpha may be responsible for the lytic mechanism during anti-tumour antibody-dependent cell-mediated cytotoxicity.
por: Pullyblank, A. M., et al.
Publicado: (1995)

Nitric oxide synthase inhibition results in synergistic anti-tumour activity with melphalan and tumour necrosis factor alpha-based isolated limb perfusions
por: de Wilt, J H W, et al.
Publicado: (2000)

Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
por: Pusztai, L., et al.
Publicado: (1994)

Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology
por: Tse, Brian W. C., et al.
Publicado: (2012)

Colorectal cancer severity and survival in correlation with tumour necrosis factor-alpha
por: Stanilov, Noyko, et al.
Publicado: (2014)

Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
por: Ruder, Barbara, et al.
Publicado: (2019)

Enhanced anti-tumour activity of carmustine (BCNU) with tumour necrosis factor in vitro and in vivo.
por: Jones, A. L., et al.
Publicado: (1990)

Effects of Adalimumab, an Anti-tumour Necrosis Factor-Alpha (TNF-α) Antibody, on Obese Diabetic Rats
por: Shuwa, Halima Ali, et al.
Publicado: (2018)

Ustekinumab Versus Anti-tumour Necrosis Factor Alpha Agents as Second-Line Biologics in Crohn's Disease
por: Eriksson, Carl, et al.
Publicado: (2023)

Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid: concomitant reduction of serum tumour necrosis factor-alpha and enhancement of anti-tumour activity.
por: Ching, L. M., et al.
Publicado: (1998)

Photodynamic therapy with mTHPC and polyethylene glycol-derived mTHPC: a comparative study on human tumour xenografts
por: Ris, H-B, et al.
Publicado: (1999)

Tumour uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma.
por: Vaage, J., et al.
Publicado: (1997)

The comparative effectiveness of abatacept versus anti-tumour necrosis factor switching for rheumatoid arthritis patients previously treated with an anti-tumour necrosis factor
por: Harrold, Leslie R, et al.
Publicado: (2015)

Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications
por: Othman, Mahmoud H., et al.
Publicado: (2022)

The neutrophil migration induced by tumour necrosis factor alpha in mice is unaffected by glucocorticoids
por: Cecilio, C. A., et al.
Publicado: (1997)

Tumour necrosis factor-alpha polymorphism as one of the complex inherited factors in pemphigus.
por: Torzecka, Jolanta Dorota, et al.
Publicado: (2003)

The promoting effect of tumour necrosis factor alpha in radiation-induced cell transformation.
por: Guo, R. F., et al.
Publicado: (1998)

Opioid receptor expression on neutrophils: effect of tumour necrosis factor alpha treatment
por: Schmidt, A, et al.
Publicado: (2007)

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis
por: Neniskyte, Urte, et al.
Publicado: (2014)

Central Nervous System Demyelination Related to Tumour Necrosis Factor Alpha Inhibitor
por: Chey, Shin Yee, et al.
Publicado: (2022)

Tumour Necrosis Factor Alpha (TNF-α) and Oral Squamous Cell Carcinoma
por: Brierly, Gary, et al.
Publicado: (2023)

Systemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy: a French national survey
por: De Bandt, Michel, et al.
Publicado: (2005)

Bactericidal activity of propylene glycol, glycerine, polyethylene glycol 400, and polyethylene glycol 1000 against selected microorganisms
por: Nalawade, Triveni Mohan, et al.
Publicado: (2015)

Hybrid Polyethylene Glycol/Sodium Metaphosphate Composites Prepared via Coacervation
por: Rodrigues, Bruno Poletto, et al.
Publicado: (2022)

Surface-grafted polyethylene glycol conformation impacts the transport of PEG-functionalized liposomes through a tumour extracellular matrix model
por: Labouta, Hagar I., et al.
Publicado: (2018)

Autocrine self-elimination of cultured ovarian cancer cells by tumour necrosis factor alpha (TNF-alpha).
por: Simonitsch, I., et al.
Publicado: (1998)

In vivo targets of recombinant human tumour necrosis factor-alpha: blood flow, oxygen consumption and growth of isotransplanted rat tumours.
por: Kallinowski, F., et al.
Publicado: (1989)

Tumour necrosis factor-alpha expression in tumour islets confers a survival advantage in non-small cell lung cancer
por: Ohri, Chandra M, et al.
Publicado: (2010)

Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model
por: Hasan, Md Mahmudul, et al.
Publicado: (2021)

Anti-tumour necrosis factor alpha therapy improves insulin sensitivity in normal-weight but not in obese patients with rheumatoid arthritis
por: Stavropoulos-Kalinoglou, Antonios, et al.
Publicado: (2012)

Synthesis of Stable Cholesteryl–Polyethylene Glycol–Peptide Conjugates with Non-Disperse Polyethylene Glycol Lengths
por: Cristóbal-Lecina, Edgar, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_63o57l6tef3dcgetj98t57um46