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Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency.

This study was conducted to increase the anti-tumour potency and reduce the toxic side-effects of tumour necrosis factor alpha (TNF-alpha). Natural human TNF-alpha was chemically conjugated with monomethoxy polyethylene glycol (PEG) using succinimidyl coupling of lysine amino groups of TNF-alpha. Th...

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Detalles Bibliográficos
Autores principales:	Tsutsumi, Y., Kihira, T., Tsunoda, S., Kanamori, T., Nakagawa, S., Mayumi, T.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1995
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033790/ https://www.ncbi.nlm.nih.gov/pubmed/7734321

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