The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.

The tumour markers carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), TPS, CA 19-9, CA 50 and CA 242 were analysed in serum from 203 potentially curable colorectal cancer patients. The levels of all markers increased with increasing tumour stage, and all markers correlated with surviv...

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Detalles Bibliográficos
Autores principales: Lindmark, G., Bergström, R., Påhlman, L., Glimelius, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033799/
https://www.ncbi.nlm.nih.gov/pubmed/7734306
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author Lindmark, G.
Bergström, R.
Påhlman, L.
Glimelius, B.
author_facet Lindmark, G.
Bergström, R.
Påhlman, L.
Glimelius, B.
author_sort Lindmark, G.
collection PubMed
description The tumour markers carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), TPS, CA 19-9, CA 50 and CA 242 were analysed in serum from 203 potentially curable colorectal cancer patients. The levels of all markers increased with increasing tumour stage, and all markers correlated with survival. Multivariate analyses indicated that the Dukes stage had the best prognostic explanatory power, followed by TPA. In the subset of 166 potentially cured patients, the prognostic information by the markers was substantially reduced. We conclude that preoperative serum tumour marker measurements have the potential to aid therapy selection, but also that their clinical usefulness is not immediately apparent.
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spelling pubmed-20337992009-09-10 The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer. Lindmark, G. Bergström, R. Påhlman, L. Glimelius, B. Br J Cancer Research Article The tumour markers carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), TPS, CA 19-9, CA 50 and CA 242 were analysed in serum from 203 potentially curable colorectal cancer patients. The levels of all markers increased with increasing tumour stage, and all markers correlated with survival. Multivariate analyses indicated that the Dukes stage had the best prognostic explanatory power, followed by TPA. In the subset of 166 potentially cured patients, the prognostic information by the markers was substantially reduced. We conclude that preoperative serum tumour marker measurements have the potential to aid therapy selection, but also that their clinical usefulness is not immediately apparent. Nature Publishing Group 1995-05 /pmc/articles/PMC2033799/ /pubmed/7734306 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lindmark, G.
Bergström, R.
Påhlman, L.
Glimelius, B.
The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.
title The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.
title_full The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.
title_fullStr The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.
title_full_unstemmed The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.
title_short The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.
title_sort association of preoperative serum tumour markers with dukes' stage and survival in colorectal cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033799/
https://www.ncbi.nlm.nih.gov/pubmed/7734306
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