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Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen.
The clinical importance of microvessel quantitation as a prognostic indicator in invasive breast cancer was examined. This study included 155 patients with invasive breast cancer, with a median follow-up of 82 months. Microvessels were identified by immunohistochemical staining for factor VIII-relat...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1995
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033832/ https://www.ncbi.nlm.nih.gov/pubmed/7779727 |
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author | Ogawa, Y. Chung, Y. S. Nakata, B. Takatsuka, S. Maeda, K. Sawada, T. Kato, Y. Yoshikawa, K. Sakurai, M. Sowa, M. |
author_facet | Ogawa, Y. Chung, Y. S. Nakata, B. Takatsuka, S. Maeda, K. Sawada, T. Kato, Y. Yoshikawa, K. Sakurai, M. Sowa, M. |
author_sort | Ogawa, Y. |
collection | PubMed |
description | The clinical importance of microvessel quantitation as a prognostic indicator in invasive breast cancer was examined. This study included 155 patients with invasive breast cancer, with a median follow-up of 82 months. Microvessels were identified by immunohistochemical staining for factor VIII-related antigen in formalin-fixed, paraffin-embedded primary tumours. For each tumour, microvessels were counted within a 200 x magnification field in the area of highest microvessel density. Microvessel counts (MVCs) had no correlation with tumour size, lymph node status or histological grade. When patients were classified by MVC, higher counts were associated with shorter disease-free survival and overall survival (P < 0.025 and P < 0.01 respectively). Multivariate analysis showed that MCV is an independent prognostic factor. Microvessel quantitation may be a useful predictor for identifying breast cancer patients at high risk for relapse and death. IMAGES: |
format | Text |
id | pubmed-2033832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20338322009-09-10 Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen. Ogawa, Y. Chung, Y. S. Nakata, B. Takatsuka, S. Maeda, K. Sawada, T. Kato, Y. Yoshikawa, K. Sakurai, M. Sowa, M. Br J Cancer Research Article The clinical importance of microvessel quantitation as a prognostic indicator in invasive breast cancer was examined. This study included 155 patients with invasive breast cancer, with a median follow-up of 82 months. Microvessels were identified by immunohistochemical staining for factor VIII-related antigen in formalin-fixed, paraffin-embedded primary tumours. For each tumour, microvessels were counted within a 200 x magnification field in the area of highest microvessel density. Microvessel counts (MVCs) had no correlation with tumour size, lymph node status or histological grade. When patients were classified by MVC, higher counts were associated with shorter disease-free survival and overall survival (P < 0.025 and P < 0.01 respectively). Multivariate analysis showed that MCV is an independent prognostic factor. Microvessel quantitation may be a useful predictor for identifying breast cancer patients at high risk for relapse and death. IMAGES: Nature Publishing Group 1995-06 /pmc/articles/PMC2033832/ /pubmed/7779727 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Ogawa, Y. Chung, Y. S. Nakata, B. Takatsuka, S. Maeda, K. Sawada, T. Kato, Y. Yoshikawa, K. Sakurai, M. Sowa, M. Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen. |
title | Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen. |
title_full | Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen. |
title_fullStr | Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen. |
title_full_unstemmed | Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen. |
title_short | Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen. |
title_sort | microvessel quantitation in invasive breast cancer by staining for factor viii-related antigen. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033832/ https://www.ncbi.nlm.nih.gov/pubmed/7779727 |
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