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Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma.

Flunarizine, a diphenylpiperazine calcium channel blocker, is known to increase tumor blood flow. It also interferes with calmodulin function, repair of DNA damage and drug resistance associated with P-glycoprotein. Flunarizine was tested for its ability to modulate either cyclophosphamide- or melph...

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Detalles Bibliográficos
Autores principales:	Castellino, S. M., Friedman, H. S., Elion, G. B., Ong, E. T., Marcelli, S. L., Page, R., Bigner, D. D., Dewhirst, M. W.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1995
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033851/ https://www.ncbi.nlm.nih.gov/pubmed/7779708

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