An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.

In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymp...

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Autores principales: O'Hanlon, D. M., Kerin, M. J., Kent, P., Maher, D., Grimes, H., Given, H. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033858/
https://www.ncbi.nlm.nih.gov/pubmed/7779725
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author O'Hanlon, D. M.
Kerin, M. J.
Kent, P.
Maher, D.
Grimes, H.
Given, H. F.
author_facet O'Hanlon, D. M.
Kerin, M. J.
Kent, P.
Maher, D.
Grimes, H.
Given, H. F.
author_sort O'Hanlon, D. M.
collection PubMed
description In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.
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spelling pubmed-20338582009-09-10 An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma. O'Hanlon, D. M. Kerin, M. J. Kent, P. Maher, D. Grimes, H. Given, H. F. Br J Cancer Research Article In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma. Nature Publishing Group 1995-06 /pmc/articles/PMC2033858/ /pubmed/7779725 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
O'Hanlon, D. M.
Kerin, M. J.
Kent, P.
Maher, D.
Grimes, H.
Given, H. F.
An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.
title An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.
title_full An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.
title_fullStr An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.
title_full_unstemmed An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.
title_short An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.
title_sort evaluation of preoperative ca 15-3 measurement in primary breast carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033858/
https://www.ncbi.nlm.nih.gov/pubmed/7779725
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