Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells.

We have analysed cell cycle variations in thymidylate synthase (TS) protein in asynchronously growing NCl H630 and HT 29 colon cancer and MCF-7 breast cancer cell lines. Western immunoblot analysis using the TS 106 monoclonal antibody revealed a 14- to 24-fold variation in TS levels between the peak...

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Detalles Bibliográficos
Autores principales: Pestalozzi, B. C., McGinn, C. J., Kinsella, T. J., Drake, J. C., Glennon, M. C., Allegra, C. J., Johnston, P. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033861/
https://www.ncbi.nlm.nih.gov/pubmed/7779704

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