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Familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies.

In a previous study in France, we reported that the relative risk of breast cancer associated with a family history of breast cancer was higher in those subjects with a history of abortions. The present study was undertaken to check the existence of this interaction in other studies and to investiga...

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Autores principales: Andrieu, N., Duffy, S. W., Rohan, T. E., Lê, M. G., Luporsi, E., Gerber, M., Renaud, R., Zaridze, D. G., Lifanova, Y., Day, N. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033867/
https://www.ncbi.nlm.nih.gov/pubmed/7669588
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author Andrieu, N.
Duffy, S. W.
Rohan, T. E.
Lê, M. G.
Luporsi, E.
Gerber, M.
Renaud, R.
Zaridze, D. G.
Lifanova, Y.
Day, N. E.
author_facet Andrieu, N.
Duffy, S. W.
Rohan, T. E.
Lê, M. G.
Luporsi, E.
Gerber, M.
Renaud, R.
Zaridze, D. G.
Lifanova, Y.
Day, N. E.
author_sort Andrieu, N.
collection PubMed
description In a previous study in France, we reported that the relative risk of breast cancer associated with a family history of breast cancer was higher in those subjects with a history of abortions. The present study was undertaken to check the existence of this interaction in other studies and to investigate whether the interaction is modified by the time at which abortions occur. Data were obtained from six case-control studies in France, Australia and Russia, with information on family history of breast cancer and abortion for 2693 breast cancer cases and 3493 controls. The interaction effect was estimated in each study separately, then combined using a multivariate weighted average. The relative risk conferred by a family history of breast cancer increased with the number of abortions (1.8 for no abortion, 1.9 for one abortion, 2.8 for two or more). There was a significant interaction between total number of abortions and family history (P = 0.04), but this was no longer significant when adjusted for other risk factors. The familial risk was highest for those who had had an abortion before first childbirth (1.9 for abortion after first childbirth, 2.7 for abortion before first childbirth). The adjusted risk associated with family history was significantly higher in those with an abortion before first childbirth (P = 0.04). Our findings suggest a synergism between familial factors and abortion. The interaction was not substantially modified by the type of abortion (spontaneous or induced) but was modified by the time at which it occurred in relation to first childbirth. This suggests an effect of abortion itself rather than predisposition to abortion. Further studies of breast cancer cases, particularly among BRCA1 gene carriers and their families, could improve our understanding of this effect.
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spelling pubmed-20338672009-09-10 Familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies. Andrieu, N. Duffy, S. W. Rohan, T. E. Lê, M. G. Luporsi, E. Gerber, M. Renaud, R. Zaridze, D. G. Lifanova, Y. Day, N. E. Br J Cancer Research Article In a previous study in France, we reported that the relative risk of breast cancer associated with a family history of breast cancer was higher in those subjects with a history of abortions. The present study was undertaken to check the existence of this interaction in other studies and to investigate whether the interaction is modified by the time at which abortions occur. Data were obtained from six case-control studies in France, Australia and Russia, with information on family history of breast cancer and abortion for 2693 breast cancer cases and 3493 controls. The interaction effect was estimated in each study separately, then combined using a multivariate weighted average. The relative risk conferred by a family history of breast cancer increased with the number of abortions (1.8 for no abortion, 1.9 for one abortion, 2.8 for two or more). There was a significant interaction between total number of abortions and family history (P = 0.04), but this was no longer significant when adjusted for other risk factors. The familial risk was highest for those who had had an abortion before first childbirth (1.9 for abortion after first childbirth, 2.7 for abortion before first childbirth). The adjusted risk associated with family history was significantly higher in those with an abortion before first childbirth (P = 0.04). Our findings suggest a synergism between familial factors and abortion. The interaction was not substantially modified by the type of abortion (spontaneous or induced) but was modified by the time at which it occurred in relation to first childbirth. This suggests an effect of abortion itself rather than predisposition to abortion. Further studies of breast cancer cases, particularly among BRCA1 gene carriers and their families, could improve our understanding of this effect. Nature Publishing Group 1995-09 /pmc/articles/PMC2033867/ /pubmed/7669588 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Andrieu, N.
Duffy, S. W.
Rohan, T. E.
Lê, M. G.
Luporsi, E.
Gerber, M.
Renaud, R.
Zaridze, D. G.
Lifanova, Y.
Day, N. E.
Familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies.
title Familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies.
title_full Familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies.
title_fullStr Familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies.
title_full_unstemmed Familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies.
title_short Familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies.
title_sort familial risk, abortion and their interactive effect on the risk of breast cancer--a combined analysis of six case-control studies.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033867/
https://www.ncbi.nlm.nih.gov/pubmed/7669588
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