Microsatellite instability in human testicular germ cell tumours.

DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci e...

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Autores principales: Huddart, R. A., Wooster, R., Horwich, A., Cooper, C. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033881/
https://www.ncbi.nlm.nih.gov/pubmed/7669575
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author Huddart, R. A.
Wooster, R.
Horwich, A.
Cooper, C. S.
author_facet Huddart, R. A.
Wooster, R.
Horwich, A.
Cooper, C. S.
author_sort Huddart, R. A.
collection PubMed
description DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats. IMAGES:
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spelling pubmed-20338812009-09-10 Microsatellite instability in human testicular germ cell tumours. Huddart, R. A. Wooster, R. Horwich, A. Cooper, C. S. Br J Cancer Research Article DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats. IMAGES: Nature Publishing Group 1995-09 /pmc/articles/PMC2033881/ /pubmed/7669575 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Huddart, R. A.
Wooster, R.
Horwich, A.
Cooper, C. S.
Microsatellite instability in human testicular germ cell tumours.
title Microsatellite instability in human testicular germ cell tumours.
title_full Microsatellite instability in human testicular germ cell tumours.
title_fullStr Microsatellite instability in human testicular germ cell tumours.
title_full_unstemmed Microsatellite instability in human testicular germ cell tumours.
title_short Microsatellite instability in human testicular germ cell tumours.
title_sort microsatellite instability in human testicular germ cell tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033881/
https://www.ncbi.nlm.nih.gov/pubmed/7669575
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AT woosterr microsatelliteinstabilityinhumantesticulargermcelltumours
AT horwicha microsatelliteinstabilityinhumantesticulargermcelltumours
AT coopercs microsatelliteinstabilityinhumantesticulargermcelltumours

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