A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.

Forty-one patients with advanced breast cancer were given carboplatin and vinorelbine as second-line therapy. Overall objective response rate was 46% (95% confidence interval 26-56%). Myelotoxicity was the most frequently observed toxic effect; grade III-IV leucopenia occurred in 46% of the patients...

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Autores principales: Iaffaioli, R. V., Tortoriello, A., Facchini, G., Santangelo, M., De Sena, G., Gesue, G., Bucci, L., Scaramellino, G., Anastasio, E., Finizio, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033957/
https://www.ncbi.nlm.nih.gov/pubmed/7577478
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author Iaffaioli, R. V.
Tortoriello, A.
Facchini, G.
Santangelo, M.
De Sena, G.
Gesue, G.
Bucci, L.
Scaramellino, G.
Anastasio, E.
Finizio, A.
author_facet Iaffaioli, R. V.
Tortoriello, A.
Facchini, G.
Santangelo, M.
De Sena, G.
Gesue, G.
Bucci, L.
Scaramellino, G.
Anastasio, E.
Finizio, A.
author_sort Iaffaioli, R. V.
collection PubMed
description Forty-one patients with advanced breast cancer were given carboplatin and vinorelbine as second-line therapy. Overall objective response rate was 46% (95% confidence interval 26-56%). Myelotoxicity was the most frequently observed toxic effect; grade III-IV leucopenia occurred in 46% of the patients. Our regimen is active as second-line chemotherapy for advanced breast cancer and warrants further evaluation.
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spelling pubmed-20339572009-09-10 A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer. Iaffaioli, R. V. Tortoriello, A. Facchini, G. Santangelo, M. De Sena, G. Gesue, G. Bucci, L. Scaramellino, G. Anastasio, E. Finizio, A. Br J Cancer Research Article Forty-one patients with advanced breast cancer were given carboplatin and vinorelbine as second-line therapy. Overall objective response rate was 46% (95% confidence interval 26-56%). Myelotoxicity was the most frequently observed toxic effect; grade III-IV leucopenia occurred in 46% of the patients. Our regimen is active as second-line chemotherapy for advanced breast cancer and warrants further evaluation. Nature Publishing Group 1995-11 /pmc/articles/PMC2033957/ /pubmed/7577478 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Iaffaioli, R. V.
Tortoriello, A.
Facchini, G.
Santangelo, M.
De Sena, G.
Gesue, G.
Bucci, L.
Scaramellino, G.
Anastasio, E.
Finizio, A.
A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
title A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
title_full A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
title_fullStr A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
title_full_unstemmed A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
title_short A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
title_sort phase ii study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033957/
https://www.ncbi.nlm.nih.gov/pubmed/7577478
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