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A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion.

Bryostatin 1 is a macrocyclic lactone derived from the marine invertebrate Bugula neritina. In vitro, bryostatin 1 activates protein kinase C (PKC), induces the differentiation of a number of cancer cell lineages, exhibits anti-tumour activity and augments the response of haemopoietic cells to certa...

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Detalles Bibliográficos
Autores principales:	Jayson, G. C., Crowther, D., Prendiville, J., McGown, A. T., Scheid, C., Stern, P., Young, R., Brenchley, P., Chang, J., Owens, S.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1995
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033979/ https://www.ncbi.nlm.nih.gov/pubmed/7640233

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